ATB 340, A MODULATOR OF SULFITE OXIDASE ACTIVITY, REDUCES OXIDATIVE STRESS IN HYPERGLYCEMIA AND STRESS EXPOSED GASTRIC MUCOSA IN OLD RATS
Journal Title: Праці Наукового товариства ім. Шевченка - Year 2018, Vol 52, Issue 2
Abstract
Sulfite oxidase (SO) is one of mitochondrial enzymes involved in H2S-pathway and multiple physiological processes, including oxidative stress. The dominant sulfide oxidation products vary in a tissue-specific manner, whatever SO/oxidative stress involved in gastric mucosa (GM) injury is unclear. Our labs has shown potent cytoprotective and anti-inflammatory effects of H2S-rich compounds, including hybrid nonsteroidal anti-inflammatory drugs (H2S-NSAIDs) but their effects on age-related metabolic dysfunction in GM exposed to long-term postprandial hyperglycemia by high fructose diet (HFD) is still unknown.
Authors and Affiliations
Yaroslav Pavlovskiy, Maksym Lutsyk, Antonina Yashchenko, Natalia Zaichko, John Wallace, Oksana Zayachkivska
Keywords
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- EP ID EP495058
- DOI 10.25040/ntsh2018.02.033
- Views 90
- Downloads 0
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