Atherogenic Dyslipidemia in Diabetic Nephropathy
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2014, Vol 10, Issue 3
Abstract
Background: Dyslipidemia plays an important role in progression of kidney disease in patients of diabetes mellitus and leads to cardiovascular complications. The present study aimed to asses atherogenic lipid profile in patients of diabetes mellitus and diabetic nephropathy. Aim: To evaluate atherogenic lipid profile in patients of diabetes mellitus and diabetic nephropathy. Settings and Designs: This cross sectional study was undertaken in the Department of Biochemistry and kidney Unit, Department of Medicine and Department of Nephrology of Government Medical College and super speciality hospital Nagpur, Maharashtra. Material and Method : Total cholesterol (TC), Triglycerides(TG), High density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), atherogenic ratio i.e. TC/HDL, LDL/HDL, was assessed in diabetes mellitus (n=50), diabetic nephropathy (n=50) and healthy individuals (n=50).Mean of biochemical parameter were compared by performing repeated measures one way ANOVA(F-test) and Post hoc multiple comparison of mean of three groups by Bonferroni t-test. Results: Values of total cholesterol, triglyceride ,LDL-C and TC/HDL, LDL/HDL were significantly higher in diabetes mellitus with diabetic nephropathy and diabetes mellitus without diabetic nephropathy but values of HDL-C (p<0.001) were significantly lower in diabetes mellitus with diabetic nephropathy and diabetes mellitus without diabetic nephropathy as compared to controls. Conclusion: Atherogenic dyslipidemia was more pronounced in diabetic nephropathy as compared to diabetes mellitus.
Authors and Affiliations
Katore Sarika D , Mahajan Bhushan H. , Fating Prasanna M. , Muddeshwar Manohar G. , Pramanik Sanjay
Keywords
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