Atherogenic Index of Plasma: A Marker for Undetectable Dyslipidaemia among Lichen Planus Patients
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 1
Abstract
ABSTRACT Introduction: Lichen Planus (LP) is a chronic inflammatory cutaneous disease. Some studies investigated its association with Dyslipidaemia as a main contributing factor for cardiovascular insults. Atherogenic Index of Plasma (AIP) is a strong factor for suspecting that risk. Aim: To investigate lipid profile and calculate AIP in LP patients to early detect atherogenic Dyslipidaemia, if present. Materials and Methods: This case-control study investigated 40 LP patients and 20 age, gender and body mass index (BMI) matched healthy volunteers. Lipid profile of all subjects was evaluated. AIP was estimated as Log {Triglycerides (TGs)/ High Density Lipoprotein-Cholesterol (HDL-C)} and accordingly, patients were categorised into high, medium and low cardiovascular risk patients. Results: Dyslipidaemia was detected in 47.5% of patients, while all control subjects had normal lipid profile (p<0.001). High Total Cholesterol (TC) and Low Density Lipoprotein-Cholesterol (LDL-C) mean values were significantly associated with LP patients as compared to controls (p<0.001 for both), while no significant differences regarding HDL-C and TG levels have been detected. AIP was significantly elevated in LP patients compared to controls (p=0.002). Most of the patients (72.5%) have high cardiovascular risk versus 30% of controls (p=0.004). About one-third of the high cardiovascular risk patients (31.9%) had no dyslipidemia. High risk patients tend to be of older age with no significant differences regarding gender or disease duration. Conclusion: AIP is a good predictor of cardiovascular risk in LP patients even in presence of normal lipid profile and should be evaluated in every case to permit earlier management.
Authors and Affiliations
Noha Mohammed Dawoud, Ola Ahmed Bakry, Mohammed Abd el Moneim Shoeib, Nora Abd El Satar Dawood
Keywords
Related Articles
- EP ID EP556261
- DOI 10.7860/JCDR/2019/39639.12496
- Views 122
- Downloads 0
Morphometric Study of Foramina Transversaria and the Incidence of Accessory Foramina in Cervical Spine of Indian Population
ABSTRACT Introduction: The Foramina Transversaria (FT) are known to exhibit variations in their size, shape and they may be absent or duplicated/triplicated. The deformation of foramina may result in derangement of neuro...
Breast Cancer Susceptibility Gene in Base Excision Repair Pathway in a Southern Indian Population
ABSTRACT Introduction: Breast cancer, the most complex multifactorial disease, one of the most common malignancies seen in females over the world. Single-Nucleotide Polymorphisms (SNPs) that occur in DNA repair genes are...
Bone Turnover Markers: An Emerging Tool to Detect Primary Osteoporosis
ABSTRACT Introduction: Osteoporosis is a global health problem, asymptomatic and noticed only after a fracture. Ten years after the cessation of ovarian function due to hormonal imbalance, women show an accelerated phase...
Dental Anxiety in Children: A Review of the Contributing Factors
ABSTRACT Dental anxiety is a challenge faced by the dental professionals while treating young children. Many factors have been reported as contributing factors that influence and affect the level of dental anxiety in chi...
Triage of Children with Severe Acute Malnutrition and its Outcome: Single Centre Cross-sectional Study
Abstract Introduction: World Health Organisation (WHO), Emergency Triage, Assessment and Treatment (ETAT) guidelines categorised three most common presentations of sick children at admission; these are Respiratory distre...