ATRIAL NATRIURETIC PEPTIDE IN METABOLIC SYNDROME OF IRAQI PATIENTS
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2018, Vol 4, Issue 10
Abstract
Background: Metabolic syndrome is a cluster of conditions associated with increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels, increasing risk of heart disease, stroke and diabetes. The atrial natriuretic peptides are secreted from cardiomyocytes in response to cardiac wall stress and play an important role in the regulation of blood pressure, intravascular volume, and cardiac remodeling; the natriuretic peptides also may exert a direct influence on lipid and glucose metabolism. Objectives: The current study aimed to investigate the role of atrial natriuretic peptide levels in metabolic syndrome of Iraqi patients. Methods: This study was conducted at Al-Hussein Teaching Hospital, Kerbala – Iraq from June, 2016 to Dec., 2017. One hundred twenty four patients with metabolic syndrome were included in this study. The subjects were interviewed for full history and physical examination. Diabetes was defined by either a history of fasting glucose ≥ 126 mg/dl (7.0mmol/l) or the use of insulin or hypoglycaemic medications. Serum atrial natriuretic peptide (ANP) levels were measured by ELISA kit. In addition to body mass index, lipid profiles, blood pressure, fasting glucose was measured. Results: The results show that there is a significant decrease in serum levels of atrial natriuretic peptide hormone in diabetic metabolic syndrome patients compared with non-diabetic metabolic syndrome patients in both sexes (P value< 0.05). Conclusion: We conclude that there was a significant association between lower ANP concentration and metabolic components studied. These findings raise the possibility that low level of ANP are a manifestation of metabolic syndrome, which might have pathophysiological implications.
Authors and Affiliations
Fadhil Jawad Al-Tu’ma
Keywords
Related Articles
- EP ID EP665707
- DOI -
- Views 208
- Downloads 0
THE TOXIC EFFECTS OF VARIOUS CONCENTRATION OF NICKEL ON SEED GERMINATION AND GROWTH OF COW PEA (VIGNA UNGUICULATA L. WALP
Nickel is available in the environment in various chemical forms due to geological, industrial and anthropogenic activities and accumulated in plants. Nickel is a trace element for normal plant growth. The high level of...
A COMPARATIVE STUDY OF SAFETY AND EFFICACY OF BETAMETHASONE ORAL MINI PULSE (BOMP) AND WEEKLY AZATHIOPRINE PULSE (WAP) IN THE TREATMENT OF ALOPECIA AREATA
Alopecia areata is an autoimmune disease, characterized by non-scarring hair loss on the scalp or any hair bearing surface.[1] Alopecia areata is common disease.[2] The lifetime risk of developing this condition is repor...
ENVIRONMENTAL RISK ANALYSIS IN PERTAMINA PIPE INSTALLATION MAINTENANCE REFINERY UNIT IV CILACAP ON KALI YASA RIVER, CENTRAL JAVA INDONESIA
PT Pertamina Refinery Unit IV Cilacap plans to carry out pipeline maintenance on a cross-country track along 5,300 meters. The activities will be carried out in the form of pipe replacement with the aim of increasing the...
UTILITY OF AGAROSE CELL BLOCK TECHNIQUE FOR FINE NEEDLE ASPIRATION, URINE AND SEROUS EFFUSIONS CYTOLOGY, IN GEZIRA STATE.
Objective: To assess utility of the agarose cell block technique based on specimen adequacy and diagnostic accuracy. Material and Methods: 63 study subjects were selected for this study, among them 12(19%) were males and...
PHENOTYPIC RESISTANCE OF NOSOCOMIAL BACTERIAL ISOLATES TO SOME ROUTINELY USED DISINFECTANTS
The rise in biocide resistance among nosocomial isolates is a well-travelled narrative and Bioaerosols are recognized causes of Hospital acquired infections. This study verifies the presence of bioaerosols in hospital wa...