ATTENUATION OF CARDIOVASCULAR RESPONSES TO LARYNGOSCOPY AND INTUBATION BY DILTIAZEM AND LIGNOCAINE: A COMPARATIVE STUDY
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2013, Vol 2, Issue 3
Abstract
The study has been designed to investigate the attenuation of cardiovascular responses to laryngoscopy and intubation by diltiazem and lignocaine. Endotracheal intubation is often associated with a hypertension and tachycardia. This response is primarily because of sympatho-adrenal stimulation, associated with laryngoscopy and endotracheal intubation. The rise in the heart rate (HR) and blood pressure increases the myocardial oxygen demand. This increase is tolerated well by normal healthy individuals. However, in patients with Ischemic heart disease (IHD), Hypertensive heart disease and cerebrovascular disease, this sudden rise of heart rate and blood pressure can produce deleterious effects, in the form of myocardial ischemia, pulmonary oedema and cerebral haemorrhage. Many methods, like beta-blockers, deep inhalational anaesthesia, intravenous lignocaine, calcium channel blockers and direct acting vasodilators, have been tried to blunt these harmful pressor responses associated with laryngoscopy and endotracheal intubation. Intravenous lignocaine is a popular method of blunting this response, because of its ability to depress the myocardium and membrane stabilization effect. Diltiazem, a calcium channel blocker can blunt these responses because of its direct acting vasodilating properties and negative chronotropic effect. In view of it, the present study was undertaken to compare the effects of 1.5 mg/kg lignocaine IV given 3 minutes before laryngoscopy and intubation, Diltiazem 0.2 mg/kg IV given 60 seconds before laryngoscopy and intubation and combination of 0.2 mg/kg of diltiazem IV and 1.5 mg/kg of lignocaine IV given 60 seconds before laryngoscope and intubation on laryngoscopic reactions. It was noted that,both lignocaine and diltiazem attenuated the pressor response to laryngoscopy and endotracheal intubation compared to control group. However, the combination of lignocaine and diltiazem gave better protection against the laryngoscopic reaction than when either of the drugs was given alone.
Authors and Affiliations
Mohan K| Department of Anaesthesia, Department of Pharmacology, Sri Sathya Sai Medical College & Research Institute, Tiruporur, Guduvancherry, Ammapettai, Sembakkam, Tamilnadu, India, Corresponding author email: koyeedoctor@gmail.com, Mohana Rupa L| Department of Pharmacology, Sri Sathya Sai Medical College & Research Institute, Tiruporur, Guduvancherry, Ammapettai, Sembakkam, Tamilnadu, India
Keywords
Related Articles
- EP ID EP11017
- DOI 10.5958/j.2319-5886.2.3.098
- Views 388
- Downloads 21
The effect of eight weeks of resistance training on serum levels of Chemerin and body composition of overweight disabled males
Chemerin is a pro-inflammatory cytokine that is newly discovered and plays an important biological role in fat tissue formation. The aim of this study was to investigate the effect of eight weeks of resistance training...
HEMOGLOBIN A1C INDUCED DOWN-REGULATION OF CD36 OF PLASMODIUM FALCIPARUM PARASITIZED RED CELL
Objective: High values of glycosylated hemoglobin have been found to correlate with decreased deformability of erythrocyte. CD36 (Cluster of Differentiation 36) is an integral membrane protein found on the surface of ma...
Atypical Presentation of Trichophyton tonsurans Mimicking Non-Healing Ulcer: A Case Report
Dermatophytosis is superfcial cutaneous fungal infection of skin, hair, and nails. Trichophyton tonsurans is an anthropophilic cosmopolitan dermatophyte most frequently associated with Tinea capitis. A 58-year-old femal...
Functional outcome of cemented bipolar hemireplacement arthroplasty in fracture neck of femur in elderly: A prospective observational study
Fractures of neck of femur have always presented great challenges to orthopaedicians and remains in many ways today “The Unsolved Fractureâ€, as was called many years ago by Dickson and Nicoll as far as treatment and...
Social media as a beneficial tool to support preterm infants and parents
Home care, continuous follow-up, and endless post discharge support play vital role in preventing the emergence of mental and physical disabilities and death among preterm infants. Providing necessary care and support f...