Attenuation of depression by Bauhinia purpurea linn. leaves ethanolic extract in swiss albino mice
Journal Title: IP International Journal of Comprehensive and Advanced Pharmacology - Year 2017, Vol 2, Issue 3
Abstract
Introduction: Depression is a characterised by low mood and lack of activity that can implicit on person's thoughts, behaviour, feelings, and sense of well-being. Objectives: To evaluate antidepressant activity of Ethanolic extract of Bauhinia Purpurea in Swiss Albino mice. Materials and Method: Sixty Swiss Albino mice of either sex weighing 20-25gm were divided into five groups, Group I received vehicle (1% Gum acacia suspension - 3ml/kg P.O), Group II received standard drug Imipramine (10mg/kg orally 1 hour before the experiment). Group III, IV, V received the test drug in the dose of 100 mg/kg, 250mg/kg, and 500mg/kg respectively. Experiment was done by Forced swim test (FST) and Tail suspension test (TST) and duration of mobility and immobility were considered during the last 4 minutes in the 6 minutes test. Statistical analysis: Dunnett’s test. P < 0.05 was considered as significant. Results: Administration of ethanolic extract of Bauhinia Purpurea at the dose of 500mg/kg produced significant decrease in immobility time in both the models with a P value of < 0.05. Conclusion: Administration of ethanolic extract of Bauhinia Purpurea at the dose of 500mg/kg has produced statistically significant decrease in immobility time in both the models.
Authors and Affiliations
Prathvi Shetty, Manohar V. R. , Sara Kurien, Mohandas Rai
Keywords
Related Articles
- EP ID EP319477
- DOI 10.18231/2456-9542.2017.0003
- Views 84
- Downloads 0
E-pharmacy vs conventional pharmacy
Pharmaceutical industry in India is the 3rd largest fastest developing industry in India Online pharmacy is one of the technology advancement in creating huge demand in the upcoming days Though it is convenient to buy d...
To analyze the variations in cost of Anti-glaucoma eye preparations available in Indian market
Aim To analyze the percentage cost variations among different brands of the commonly prescribed antiglaucoma drugsMaterial and Methods The maximum and minimum price of each brand of the drug in INR was noted by using CIM...
A study on analogy and similitude in relation to tear stability and tear flow by using Schirmer\'s tear test and Fluorescein dye in patient attending south Indian tertiary care hospital
Introduction A stable tear film precorneal film with normal flow is essential for preserving a clear cornea It gets affected in day to day life and results in dry eye syndrome due to irritation stress dust fumes toxins a...
Biofilm formation and extended spectrum beta-lactamase production in Klebsiella pneumoniae isolates from respiratory samples in a tertiary care hospital
Nosocomial and community acquired infections are being caused by Klebsiella pneumoniae K pneumoniae worldwide K pneumoniae among gram negative organisms is an important bacterium responsible for site specific infection w...
Profile and Outcome of Tuberculosis treatment in a Non Government tertiary centre in South India
Introduction: To study the Profile and Outcome of patients undergoing treatment for TB in a tertiary care hospital in South India. Materials and Method: All patients diagnosed with Tuberculosis in the facility during the...