Attenuation of stress response to laryngoscopy and intubation: Sublingual nitroglycerin spray vs intravenous fentanyl and sublingual nitroglycerin spray
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 4
Abstract
Background and aim: Laryngoscopy and endotracheal intubation is associated with cardiovascular changes such as tachycardia and hypertension which may be detrimental to patients with limited cardiovascular reserve. Many pharmacological agents have been used to attenuate the stress responses but none has been found ideal. Our aim of this study is to compare the efficacy of sublingual Nitroglycerine spray alone and sublingual Nitroglycerine spray with intravenous Fentanyl to attenuate the stress response to laryngoscopy and endotracheal intubation. Methods: A total of 90ASA I and II patients of age group 20-60 years scheduled for elective surgery under general anesthesia were randomly divided into 3 groups of 30 in each group. Group 1 received normal saline (control group), Group 2 received NTG sub-lingual spray (0.4mg/spray) two min. before induction, and Group 3 received inj. Fentanyl (2µg/kg) 5min before induction + NTG sub-lingual spray (0.4 mg/spray) 2min before induction. Vital parameters like HR,SBP,DBP and MAP before and after induction and thereafter at specified time interval following laryngoscopy and intubation were recorded and analyzed. Results: Demographic characteristics and baseline parameters in both the groups were comparable. Significant differences in parameters like SBP,DBP, MAP and heart rate were recorded in between the groups after intubation. Conclusions: Combination of intravenous Fentanyl plus Nitroglycerin spray is more potent than NTG spray alone in preventing the stress response following laryngoscopy and endotracheal intubation.
Authors and Affiliations
Dr. Sidharth Sraban Routray
Keywords
Related Articles
- EP ID EP505164
- DOI -
- Views 126
- Downloads 0
Long Term Outcome of A Tmj Discectomy. Pseudo- Disc Formation after Silastic Implant. Case Report and Short Literature Review.
Temporomandibular joint disorders (TMJ) are a widespread cause of facial pain, headaches, joint noises and limited mouth opening. TMJ disc displacement is the most common disorder whereas benign tumors involving the TMJ,...
Sociodemographic and health profile of construction workers of Central India: A cross sectional study.
Background: Occupational hazards contribute to morbidity and mortality of millions of people worldwide and result in the ill health or disablement of hundreds of millions more each year. Working on a construction site or...
Post Traumatic Shoulder Pathology – Is conventional Magnetic Resonance Imaging still useful..?
Objective: Non –invasive conventional Magnetic resonance imaging is a routine diagnostic investigation carried out in patients of gleno-humeral pathology; however, the gold standard modality to evaluate these lesions is...
Assessment of the Epidemiological Factors and Their Relationship with Non Syndromic Cleft Lip and Cleft Palate Patients of 0-24 Months Old, Attending a Tertiary Care Hospital in Bangalore: A Cross Sectional Study
Background: Cleft lip or palate is a congenital opening or fissure occurring in the lip or palate. Many environmental factors have been examined in epidemiologic studies of risk factors for oral clefts. For many of these...
Awareness, Attitude and Practices of Biomedical Waste management among health care workers of private nursing homes in West Bengal.
Introduction: According to Bio-Medical Waste (Management and Handling) Rules, of India Biomedical waste (BMW) includes waste generated during diagnosis, treatment or immunization of human beings or animals or research ac...