Attenuation of sympathetic pressor responses to laryngoscopy and intubation in patients with preeclampsia: Comparison between IV lignocaine and IV lignocaine with labetalol
Journal Title: Indian Journal of Clinical Anaesthesia - Year 2018, Vol 5, Issue 1
Abstract
Introduction: tracheal intubation and laryngoscopy are invariably associated with reflex sympathetic pressor responses resulting in elevated HR & BP. This may prove detrimental in preeclampsia patients. Objectives: To compare the efficacy of adding labetalol 0.5mg/kg IV to lignocaine 1.5mg/kg IV for attenuating increases in HR,SBP,DBP and MAP during laryngoscopy and intubation under general anaesthesia in parturients with preeclampsia posted for LSCS and to study the incident of any side effects. Materials and Methods: 60 patients with mild PIH presenting for LSCS, either elective or emergency, under GA were studied and randomly allocated to one of the two groups of 30 patients each. All patients were premedicated with inj glycopyrrolate 0.01mg/kg IV, inj fentanyl 1 µg/kg along with study drug labetalol 0.5mg/kg given 5minutes before laryngoscopy and intubation. Patients were induced with thiopentone 5mg/kg IV and succinylcholine 2mg/kg IV, preservative free lignocaine 1.5mg/kg IV given 2minutes before intubation. HR, SBP, DBP were recorded before and after intubation, at 1st, 3rd, 5th and 10th minutes. Results: Rise in the HR,SBP,DBP,MAP were observed in both the groups at one minute following laryngoscopy and intubation and these responses persisted for about 3 minutes after which they returned towards basal values and below the baseline in case of group 1(labetalol with lignocaine) compared to group 2(lignocaine) in preeclampsia. Conclusions: Adding labetalol 0.5mg/kg IV to lignocaine 1.5mg/kg IV is effective in further attenuation of haemodynamic response to laryngoscopy and intubation in preeclampsia patients.
Authors and Affiliations
Asha G.
Keywords
Related Articles
- EP ID EP472744
- DOI 10.18231/2394-4994.2018.0011
- Views 100
- Downloads 0
Comparison of intraocular pressure and hemodynamic responses to insertion of laryngeal mask airway or endotracheal tube in elective paediatric ophthalmic procedures
Introduction The main objective of the study was to assess the benefits of using laryngeal mask airway in place of endotracheal intubation in reducing the intraocular pressure and hemodynamic response in paediatric patie...
Comparative evaluation of induction characteristics of Propofol and Etomidate during general anaesthesia
Introduction: In general anaesthesia, induction of patients with intravenous anaesthetic agents is a common practice. Induction is a very crucial time as at this time the patient is liable to undergo sudden unexpected ha...
Knowledge of 2015 basic life support (BLS) guidelines among doctors and nursing staff of a rural based tertiary care hospital, in western India: Current status and requirement
Background & Aim: The chances of return of spontaneous circulation and survival to hospital discharge increase after cardiac arrest with high quality cardiopulmonary resuscitation (CPR). In the era of evidence based medi...
Oral gabapentin for postoperative pain relief after lower limb surgery – a randomized controlled trail
Introduction: In addition to anticonvulsant property of gabapentin, it was demonstrated that gabapentin also possesses analgesic property. In this randomized control trial the efficacy of gabapentin for postoperative pai...
A study to evaluate comparative efficacy of two different venous occlusion duration on pretreatment with Inj. lignocaine to prevent propofol Inj. pain in patients undergoing surgery under general anaesthesia
Aim To study the efficacy of two different time duration of venous occlusion in preventing propofol injection painMaterials and Methods In this prospective randomized controlled study patients of either gender scheduled...