Atypical celiac disease in riskgroup in children
Journal Title: Pediatria Współczesna. Gastroenterologia, Hepatologia i Żywienie Dziecka - Year 2006, Vol 8, Issue 2
Abstract
Introduction: During last 20 years clinical course of celiac disease changed mostly into atypical, often with clinical manifestation outside of the gastrointestinal tract. Objectives: The aim of the study was to evaluate the prevalence of atypical celiac disease in riskgroups of children. Materiał and methods: We studied 645 children aged 7 months-17.5 years with irritable bowel syndrome (IBS) (n=219), epilepsy (n=74), attention-deficit/hyperactMty disorder (ADHD) (n=93), autism (n=62), short stature and Iow weight (n=112) and the group with other symptoms (n=85) including anaemia, autoimmune hepatitis, idiopathic hypertransaminaesemia, cirrhosis and osteoporosis. In all patients im- munofluorescence anti-endomysium (EmA) and immunoenzymatic anti-transglutaminase (tTC) antibody tests were performed. In case of positive serological tests a smali bowel biopsy was taken for histological analyses according Marsh scale. Results: Positive screening tests were found in 11 children (the prevalence 1:58) having symptoms of IBS (n=4, 1:54), ADHD (n=3, 1:31), short stature and Iow weight (n=2, 1:56), anaemia (n=1), cirrhosis (n=1). Histological analysis showed signs of mucosa damaged in 8 out of 10 analyzed biopsies. Normal mucosa was found in 2 children with ADHD. Five children presented Marsh III lesions, one Marsh II and two Marsh I. Children with Marsh III were affected by IBS (n=3), cirhosis (n=1) and anaemia (n=1), with Marsh II by IBS (n=1), with Marsh I by ADHD and short stature and Iow weight. Conclusions: Duetothehigh prevalence of atypical celiac disease, screening test should be performed at least in riskgroups of children.
Authors and Affiliations
Barbara Burda-Muszyńska, Beata Oralewska, Bożena Cukrowska, Maria Zielińska-Michałkiewicz, Marzena Olszaniecka, Anna Stolarczyk, Jerzy Socha
Keywords
Related Articles
- EP ID EP82631
- DOI -
- Views 157
- Downloads 0
Enterocolitis preceding the diagnosis of Hirschprung's disease in a 5-month old girl
A case is presented of a 5-month old girl with no chronic constipation in whom a Hirschprung's disease was diagnosed after severe enterocolitis.
Helicobacter pylori infection in children and their appetite, according to parents’ estimation
Introduction: The infection of Helicobacter pylori affects the extraction of ghrelin and leptine by gastric mucosa, which are of great importance for the regulation of appetite. Aim of the study: The main object of this...
Atypical celiac disease in riskgroup in children
Introduction: During last 20 years clinical course of celiac disease changed mostly into atypical, often with clinical manifestation outside of the gastrointestinal tract. Objectives: The aim of the study was to evaluate...
Krwawienia z przewodu pokarmowego u dzieci
Jednym z najbardziej niepokojących objawów chorobowych w klinice dziecięcej jest krwawienie z przewodu pokarmowego. Może być ono następstwem chorób ogólnoustrojowych (np. choroba Schonleina-Henocha, zespół hemolityczno-m...
Chronic abdominal pain in children
Except for infectious diseases abdominal pain is the most frequent complain in childhood. In this review functional abdominal pain is de-scribed which is defined as chronić pain not related to structural and biochemical...