Auto-antibodies to protein Z in patients undergoing off-pump coronary artery bypass surgery – preliminary results

Journal Title: Diagnostyka Laboratoryjna - Year 2018, Vol 54, Issue 4

Abstract

Background: Considerable attention has been focused over the past several years on the protein Z (PZ) system. However, little is known about the role of auto-antibodies to PZ (anti-PZ) in cardiac surgery patients. Aim: In the present pilot study, we investigated plasma levels of anti-PZ in patients undergoing off-pump coronary artery bypass (OPCAB) surgery. Material and methods: Thirty patients with coronary artery disease scheduled for OPCAB surgery were enrolled in this study. Plasma levels of anti-PZ IgM and anti-PZ IgG were measured before surgery and one week after surgery using enzyme-linked immunosorbent assay. Results: None of the subjects were shown to have positive results for anti-PZ IgM and anti-PZ IgG either before and one week after OPCAB surgery. Conclusions: These results suggest that anti-PZ autoantibodies are not an effective component of the PZ system in OPCAB patients

Authors and Affiliations

Artur Słomka, Aleksandra Piekuś, Mariusz Kowalewski, Giusseppe Maria Raffa, Kamil Kozerawski, Wojciech Pawliszak, Lech Anisimowicz, Ewa Żekanowska

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  • EP ID EP620720
  • DOI -
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How To Cite

Artur Słomka, Aleksandra Piekuś, Mariusz Kowalewski, Giusseppe Maria Raffa, Kamil Kozerawski, Wojciech Pawliszak, Lech Anisimowicz, Ewa Żekanowska (2018). Auto-antibodies to protein Z in patients undergoing off-pump coronary artery bypass surgery – preliminary results. Diagnostyka Laboratoryjna, 54(4), 241-244. https://www.europub.co.uk/articles/-A-620720