Autoimmune thyroiditis – Correlation of clinico-radiological presentation, thyroid profile and cytomorphological spectrum
Journal Title: International Archives of Integrated Medicine - Year 2018, Vol 5, Issue 1
Abstract
Background: Thyroiditis is the second most common thyroid lesion next to endemic goitre diagnosed on FNA in iodine (I2) deficient areas. Although FNAC is the gold standard for diagnosis of thyroiditis, accurate diagnosis of a thyroid lesion at FNAC requires not just an in depth study of the cytomorphology but also a thorough clinico- radiological and serologic correlation. Aim: To study and correlate the clinical, radiologic, serologic and cytomorphological spectrum of autoimmune thyroiditis. Materials and methods: Retrospective study involving 150 cases was conducted. Clinical history (age, sex, symptoms with their duration and other signs, other significant medical/surgical history), TFT, were noted from the medical record available with the patient and also from Endocrinology department records. Results: Incidence of autoimmune thyroiditis was found to be 13.4%. Majority of the patients were females (96.7%), 53.3% of cases were seen in the age group of 21-40 years. 80.6% patients had a diffusely enlarged thyroid gland clinically. 92.7% patients showed grade I/II goitre. USG also showed a diffuse enlargement in 85.3% cases. Of the 150 patients with autoimmune thyroiditis, 110(73.3%) patients were euthyroid while 32 (21.3%) patients were hypothyroid at the time of FNAC. Only 8(5.3%) patients showed evidence of hyperthyroidism. 8% patients showed subclinical hypothyroidism. Prevalence of euthyroid autoimmune thyroiditis appeared high in our study. Among the cytomorphological features, presence of lymphocytes was consistently seen in all cases of chronic lymphocytic thyroiditis /mixed thyroiditis. Hurthle cells were seen in 68.6%, eosinophils were seen in 16.6%, giant cells and granulomas were noted in 29.3% and 8.6% cases respectively. L:E ratio was high in 101 (67.3%) cases ranging from 2:1 to 10. TFC destruction and grade III thyroiditis showed a significant association. Conclusion: Autoimmune thyroiditis was seen more commonly in females. Majority cases were seen in age group of 21-40 years of age. Lymphocytes, germinal centre cells, thyroid follicular destruction and Hurthle cells form important cytological features, while giant cells, eosinophils, granulomas were other cytomorphologic features in the diagnosis of autoimmune thyroiditis. Clinically and radiologically most of patients showed diffuse enlargement of thyroid gland. Majority of patients in our study were euthyroid at time of presentation. Prevalence of euthyroid autoimmune thyroiditis appeared high in our study. TFC destruction and grade III thyroiditis showed a significant association.
Authors and Affiliations
Shweta P. Bijwe, Arunkumar D. Chopwad
Keywords
Related Articles
- EP ID EP413505
- DOI -
- Views 128
- Downloads 0
Retrospective study of ectopic pregnancy in tertiary care centre
Background: Ectopic pregnancy is one in which fertilized ovum become implanted in site other than normal uterine cavity. Ectopic pregnancy commonly occurs in the fallopian tube. Ectopic pregnancy is the leading cause of...
Prevalence of symptomatic peptic ulcer in diabetes mellitus patients at out patient department of government medical college and hospital in and around villupuram district
Introduction: A peptic ulcer is a sore that forms when digestive juices wear away the lining of the digestive system. A peptic ulcer can occur in the lining of the stomach, duodenum, or lower part of the esophagus. Sympt...
A study of cardiovascular involvement in Hypothyroidism
Background: Cardiac abnormalities associated with hypothyroidism attracted great deal of investigational effort. There are only few studies done in our country to asses CVS parameters in hypothyroid patients. Hypothyroid...
Sequential use of clomiphene citrate and human menopausal gonadotropin in anovulatory infertility
Background: Infertility is a complex disorder with significant medical, psychosocial and economic aspects. Infertility causes great distress to many couples, causing increased numbers of them to seek specialist fertility...
Effect of electronic gadgets on cognitive milestones of children below 2 years of age
The purpose of this research was to determine the effect of electronic gadgets on cognitive milestones of children below 2 years of age. While conducting the research methods used were, 100 children of age group 6 months...