Autologous stem cell transplantation (ASCT) as a remission consolidation offers a durable survival benefit in patients with peripheral T-cell lymphomas (PTCL)
Journal Title: Postępy Nauk Medycznych - Year 2011, Vol 24, Issue 6
Abstract
Introduction. Peripheral T-cell lymphomas (PTCL) comprise a heterogeneous group of malignancies which are characterized by an aggressive disease course and a poor outcome after conventional chemotherapy.Material and methods. We analyzed the results of ASCT in 29 patients with advanced stage PTCL. Patients were transplanted after achieving first complete or partial remission after conventional chemotherapy.Results. Twenty nine patients (15 male and 14 female) at a median age at diagnosis of 45 years (range 20-66 years) were analyzed. The study cohort included 13 with PTCL unspecified (PTCL-U) and 16 patients with anaplastic large cell lymphoma (ALCL). Most patients had advanced disease stage at diagnosis (III and IV Ann-Arbor) and B symptoms. International prognostic index (IPI) ≥ 2 was demonstrated in 10 PTCL-U and 6 ALCL patients. Induction chemotherapy consisted of a median of six CHOP cycles (range 1-10). The median number of all cycles before ASCT was 8 (range 3-20) and 7 (range 3-18) for PTCL-U and ALCL, respectively. The disease status at transplant was as follows: complete remission (CR; n = 8) and partial remission (PR; n = 5) for PTCL-U and 8 CR and 8 PR for ALCL. Conditioning regimen before ASCT consisted of CBV and BEAM for 15 and 14 patients, respectively. Among 29 transplanted patients, 7 died due to disease progression. 22 patients remain in CR. The 3-year probability of the overall survival (OS) and progression-free survival (PFS) for whole group were 79 and 70%, respectively.Conclusions. We have confirmed that ASCT as consolidation therapy for PTCL is a safe and efficient procedure.
Authors and Affiliations
Grzegorz Helbig, Tomasz Kandzia, Marcin Kubeczko, Maria Liszka, Klaudyna Machura, Małgorzata Makowska, Sławomira Kyrcz-Krzemień
Keywords
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