B-Cell Targets to Treat Antibody-Mediated Rejection in Transplantation
Journal Title: International Journal of Transplantation Research and Medicine - Year 2016, Vol 2, Issue 2
Abstract
Abstract: Antibody-mediated rejection (AMR) in allograft transplantation can be defined with a rapid increase in the levels of specific serological parameters after organ transplantation, presence of donor specific antibodies (DSAs) against human leukocyte antigen (HLA) molecules, blood group (ABO) antigens and/or endothelial cell antigens (e.g. MICA, ECA, Vimentin, or ETAR) and also particular histological parameters.
Pharmacological Conditioning of Brain Dead Donor Hearts with Erythropoietin and Glyceryl Trinitrate: Clinical Experience
Background:With the increasing success of heart transplantation, older and higher-risk donors and recipients are being accepted for transplantation. The risk of primary graft dysfunction (PGD) is thus increased. We inves...
Transplantation of Decellularized Venous Valvular Grafts in an Ovine Model
The surgical treatment of end-stage chronic venous insufficiency involves valvular repair or transplantation to restore venous valve function and structure. Current valve substitutes can have issues with durability, thro...
Treatment of Coronary Artery Fistula Post-Cardiac Transplantation with Covered Stent: A Case Study and Review of Literature
The majority of coronary artery fistulas are congenital and discovered incidentally on coronary angiography. Coronary artery fistulas may also develop after cardiac transplantation as a complication of endomyocardial bio...
Sustained In Vivo Perfusion of a Re-Endothelialized Tissue Engineered Porcine Liver
Objective A tissue engineered liver graft will provide a sustainable source of transplantable organs. A porcine liver scaffold was utilized to develop a re-endothelialized revascularized liver capable of sustained in viv...
Distinctive CD8 T Cell Infiltration and Paucity of Regulatory T Cells in Chronic Graft-Versus-Host-Disease Lesions
Alterations in immune reconstitution have been implicated with the development of chronic graft-versus-host disease (cGVHD) in allogeneic bone marrow transplantation (BMT) recipients. Since T cells are important mediator...