Bacterial, viral and fungal infections in primary immunodeficiency patients

Journal Title: Advances in Hygiene and Experimental Medicine - Year 2018, Vol 72, Issue

Abstract

Primary immunodeficiency diseases (PIDs) are genetic based disorders which lead to the dysfunction of the immune system. There are persistent and recurrent infections within PID patient due to cellular and humoral immunity impairment. The most common infections are caused by Salmonella Enteritidis, Shigella flexneri, Mycobacterium avium complex, Toxoplasma gondii, CMV, Candida albicans, Cryptococcus neoformans or Pneumocystis jiroveci. These infections have a severe course of disease with limited treatment in a conventional way. Full patient recovery after intensive and long-term therapy is often impossible. Viral infections in PID patients are equally frequent. The incidences of Herpesviridae and HCV infections are the same for PID patients and healthy people. However, the infections may have worse course of disease and leave more destruction in the body. Enteroviral infections occur despite the antibodies supplementation; they spread spontaneously throughout the body, also affecting the central nervous system. Skin, nails and mucous membranes infections are equally persistent problems caused by fungi, mainly Candida genus. Infections with these pathogens are often accompanied by hormonal disorders and immunosuppressive therapy. Sepsis and mixed infections are definitely the most dangerous for patients with infections. Infections occur most often in the first years of the child’s life, when the body has not developed yet a fully functioning immunity system. The diagnosis of PNO in infants may be difficult due to the presence of antibodies from mother and the similarity of the symptoms of infectious diseases and common infections.<br/><br/>

Authors and Affiliations

Piotr Naporowski, Danuta Witkowska, Aleksandra Lewandowicz-Uszyńska, Andrzej Gamian

Keywords

Related Articles

Dehydroepiandrosterone sulfate, osteoprotegerin and its soluble ligand sRANKL and bone metabolism in girls with anorexia nervosa

Background: Only scarce data exist concerning the relationship between dehydroepiandrosterone (DHEA) and/or its sulfate form DHEAS and bone status in adolescents with anorexia nervosa (AN). Aim: We investigated whether...

18 kDa translocator protein – implications in cell’s functions

The mitochondrial 18kDa Translocation Protein (TSPO) was first identified in 1977 by its capability to bind benzodiazepines in peripheral tissues. It is more commonly known after its previous name – peripheral benzodiaze...

Biochemia i terapeutyczny potencjał siarkowodoru – rzeczywistość czy fantazja?

Siarkowodór (H2S) jest sygnalizacyjnym gazotransmiterem, który bierze udział w różnych procesach fizjologicznych i patologicznych. H2S reguluje apoptozę, cykl komórkowy i stres oksydacyjny. H2S wywiera silny wpływ na kom...

Dipeptidyl peptidase IV: An attractive target for the development of effective diagnostic and therapeutic strategies

DPP IV is a peptidase with a catalytic activity and the ability to bind extracellular matrix proteins. It participates in the metabolism of glucose, gastrointestinal motility, the regulation of appetite and affects the f...

Pozażywieniowe możliwości wykorzystania mleka kobiecego

Mleko ssaków, poza składnikami odżywczymi, zawiera wiele aktywnych biologicznie substancji w tym między innymi: immunoglobuliny, czynniki wzrostu, cytokiny, białka ostrej fazy, białka o właściwościach przeciwbakteryjnych...

Download PDF file
  • EP ID EP343207
  • DOI 10.5604/01.3001.0012.1734
  • Views 168
  • Downloads 0

How To Cite

Piotr Naporowski, Danuta Witkowska, Aleksandra Lewandowicz-Uszyńska, Andrzej Gamian (2018). Bacterial, viral and fungal infections in primary immunodeficiency patients. Advances in Hygiene and Experimental Medicine, 72(), 557-572. https://www.europub.co.uk/articles/-A-343207