Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance
Journal Title: Journal of Medical and Allied Sciences - Year 2014, Vol 4, Issue 1
Abstract
The objective of this study was to isolate pathogenic bacteria in neonatal septicaemia cases, and to know their antibiograms. Under aseptic precautions, blood was drawn from 140 neonates with suspected septicaemia and inoculated in BHI broth. Isolates obtained were identified as per standard protocol and antibiotic susceptibility was done by Kirby Bauer disc diffusion method (as per CLSI guidelines). A total number of 62 (44.2%) patients had positive blood cultures. The most common pathogens isolated were Klebsiella pneumoniae (n=22, 35%) followed by Staphylococcus aureus (n=15, 24.1%), Escherichia coli (n=14, 22.5%), CONS (n=7, 11.2%) and Pseudomonas aeruginosa (n=4, 6.4%). The Gram negative organisms showed high resistance to commonly used antibiotics and were highly sensitive to Meropenem. The Gram positive bacteria showed high resistance to Ampicillin, Erythromycin and Amoxycillin; but they were highly susceptible to Linizolid and Vancomycin. As the Gram negative organisms were the most common isolates in neonatal septicaemia, their resistance pattern should be considered essential for deciding the empirical treatment. Prompt treatment of neonatal sepsis with judicious use of appropriate antibiotics can minimize the morbidity and mortality, besides reducing the emergence of multi-drug resistant organisms in ICU’s.
Authors and Affiliations
Maimoona Mustafa | Department of Microbiology, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad-500058, Andhra Pradesh, India, Syed Laeeq Ahmed| Department of Microbiology, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad-500058, Andhra Pradesh, India
Keywords
Related Articles
- EP ID EP12700
- DOI -
- Views 395
- Downloads 24
Free radicals, oxidative stress and importance of antioxidants in human health
Reactive oxygen species (ROS) is a collective term used for oxygen containing free radicals, depending on their reactivity and oxidizing ability. ROS participate in a variety of chemical reactions with biomolecules lea...
Sturge-Weber syndrome
Sturge–Weber syndrome (SWS) is a rare congenital disorder belongs to a group of disorders collectively known as the phakomatoses (“mother-spot†diseases). It consists of congenital hamartomatous malformations th...
Determinants of contraceptive use among married women residing in rural areas of Belgaum
Today the world population is around 7 billion and India harbours 1.2 billion. One of the reasons for uncontrolled growth of the population is unregulated fertility. Unregulated fertility many a times leads to unintend...
Effect of Allopregnenalone (AP) and 4′- Chlorodiazepam (4′CD) on the Lindane-induced acute and chronic convulsive behavior in rats
Neurosteroids (NS) are considered important modulators of brain functions. Lindane a pesticide has been shown to affect the nervous system adversely. The present study was designed to explore the modulation of the effe...
High Mallampati score, obesity and obstructive sleep apnea: Triple insult to lung function?
The paper assesses the combined effect of high Mallampati score, obesity and obstructive sleep apnea (OSA) on lung function as measured by spirometry. Our results showed that the combination of sleep apnea, obesity an...