Bacteriology and Antibiotic Resistance Pattern in Neonatal Septicemia
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 4
Abstract
Introduction: Neonatal septicemia is a major cause of mortality and morbidity among neonates around the world, even after advancements in antibacterial therapy. However rationale antibiotic treatment depends upon the hospital antibiotic policy which in addition to neonatal life support measures and the early detection of risk factors may be useful in treating these patients with a better outcome. Hence the present study was conducted to look for spectrum of bacterial isolates in cases of neonatal septicemia, and their antimicrobial resistance pattern. Material and methods: In this prospective study in central India, neonates suspected to be having septicemia were enrolled. Those who were on antimicrobial treatment were excluded. Detailed history and clinical findings were noted. One to two millilitre of blood was collected and inoculated in brain heart infusion broth. Blood Culture and Antibiotic susceptibility testing were performed as per standard protocols. Detailed history and clinical findings were recorded. Data was analysed using SPSS software. Results: Out of 80 cases studied, bacterial growth was obtained in 41(51.25%) blood samples. Klebsiella (46.3%), followed by S.aureus (29.2%) were the most common isolates. E.coli (9.7%), CONS (4.8%) and others like Pseudomonas aeruginosa, Enterobacter cloacae, Proteus vulgaris, Citrobacterfreundii were less frequent isolates. Among all isolates, resistance to penicillin and ampicillin was frequent. Case fatality rate (CFR) was significantly higher in the culture positive group. Sepsis with MODS was the most common causes of death in clinically suspected culture negative group, followed by sepsis with pneumonia. Conclusion: Here it is recommended that Choice of antibiotics should be based on routine surveillance of sensitivity pattern of particular organism.
Authors and Affiliations
Riti Jain Seth
Keywords
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