Badania nanokompozytów hydroksyapatytowych wobec bakterii beztlenowych
Journal Title: Wiadomości Chemiczne - Year 2018, Vol 72, Issue 7
Abstract
Nanocrystalline apatites Ca10(PO4)6(OH)2(HAp) non-doped and doped with Ag+and Eu3+ions were synthesized by different wet chemistry methods. The obtained hydroxyapatite was loaded with Ag0, as well as nitroimidazole antimicrobials: metronidazole and tinidazole. The antimicrobial activity of the obtained materials against Prevotella bivia and Parabacteroides distasonis was studied. The method used for the antibacterial susceptibility testing was broth microdilution, according to the CLSI – Clinical and Laboratory Standard Institute – standard M11-A8; agar Schaedler, enriched with 50% LHB - Lysed Horse Blood, was used as a medium for culturing strains. The antibacterial activity increased for the immobilized antibiotics – HAp doped with metronidazole and tinidazole was six times more bactericidal than non-immobilised metronidazole for both clinical isolates. In comparison with non-immobilised tinidazole, HAp immobilised with tinidazole was six thousand times more effective against P. distasonis and two hundred times more effective against P. bivia. HAp doped with tetracycline was over two times more bactericidal than tetracycline non-immobilised (according to the literature data). The exact MIC for bionanocomposites of HAp and silver was not obtained. The research shows that bionanocomposites of hydroxyapatite are good drug carriers for both antibiotics and silver particles and ions. The use of bionanocomposites of apatite immobilised with antibiotics in dentistry could result in a prolonged antibacterial activity of these compounds.
Authors and Affiliations
Anna Kędziora, Agata Bernat, Rafał Jakub Wiglusz
Keywords
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