BARLERIA MONTANA WIGHT AND NEES–A PROMISING NATURAL ANTI-INFLAMMATORY AGENT AGAINST FORMALIN INDUCED INFLAMMATION
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 9
Abstract
Objective: To evaluate the anti-inflammatory activity of the ethanolic leaf extract of Barleria montana (B. montana) against formalin induced inflammation.Methods: Male albino wistar rats were pretreated with oral doses of 100 mg, 200 mg and 300 mg of the extract for 30 days and the animals received a single dose of sub plantar injection of formalin (0.1 ml/kg body weight (bw.)) Indomethacin (25 mg/kg bw.) was used as the standard drug. The effect of the extract on paw thickness, biochemical and hematological parameters was investigated along with histopathological studies.Results: The results revealed that the extract exhibited an effective dose dependent activity against formalin induced inflammation with a maximum activity at a dosage of 300 mg/kg bw. which was comparable with the standard drug.Conclusion: The results signify promising activity of ethanolic leaf extract of B. montana against formalin induced inflammation in albino rats. The extract was also found to exhibit appreciable antioxidant activity.Â
Authors and Affiliations
Sriram Sridharan, Meenaa Venkatramani, Kavitha Janakiraman, Brindha Pemiah, Sasikumar Chinnagounder
Keywords
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