Benign endometrial lesions in premenopausal women: three-dimensional power Doppler sonography and cytokines content
Journal Title: Progress in Health Sciences - Year 2013, Vol 3, Issue 2
Abstract
Purpose: To investigate the IL-2, IL-4, IL-6, IL-8, IL-10, TNF-a, IL-1β, IFN-γ at the local and system levels in endometrial polyps and hyperplasia in premenopausal women; to assess whether three-dimensional power Doppler indices can discriminate between hyperplasia and proliferative endometrium. Materials and methods: The prospective analysis included 80 premenopausal women with the suspicion of endometrial hyperplasia and endometrial polyp according to 2D ultrasonography data. Three groups of patients were analyzed according to histological data. There were 25 women with simple endometrial hyperplasia without atypia (the first study group), 15 patients with hyperplastic endometrial polyps (the second study group) and 40 healthy women with endometrium in the early proliferative phase (control group) in premenopausal age. The levels of some cytokines were determined by enzyme linked to immunosorbent assay in serum and in aspirates from the uterus cavity. Three-dimensional power Doppler indexes of the uterus and endometrium were measured in endometrial hyperplasia and proliferative endometrium. Results: Significant dysfunctional changes of local immune system of uterine mucosa in endometrial hyperplasia and endometrial polyp are expressed in activation of pro-inflammatory cytokines, with a deficit of anti-inflammatory cytokines. Endometrial three-dimensional power Doppler indices of uterine and endometrium were significantly higher in endometrial hyperplasia. Conclusions: The local secretion imbalance of pro- and anti-inflammatory cytokines is present in endometrial hyperplasia and polyps in premenopausal age. Endometrial perfusion increases in endometrial hyperplasia by using three-dimensional power Doppler sonography in comparison with healthy women.
Authors and Affiliations
OV Lysenko
Keywords
Related Articles
- EP ID EP75335
- DOI -
- Views 96
- Downloads 0
The oncoprotein HBXIP – its functions and roles in oncogenesis
Nowadays, Hepatitis B X interacting protein (HBXIP) is an object of scientists’ interest worldwide. It is a protein with significant involvement in the development of malignant tumors like breast or ovarian cancer. One o...
Fluid velocity during embryo transfer
Purpose: The embryo transfer into the uterus by a transcervical catheter is the final stage of in-vitro fertilization procedure. So far, a little attention has been placed on the impact of embryo transfer procedure on em...
Risk of addiction to Facebook among Medical University students in Białystok, Poland
Introduction: Facebook is the most popular socialnetworking website in the world. It is estimated that it currently has more than 350 million users worldwide. Purpose; To assess the risk of addiction to Facebook the risk...
Assessment of the knowledge and application of the Mediterranean diet among students of dietetics
<b>Purpose:</b> To assess the knowledge of young adults (students of dietetics) of the health benefits of the Mediterranean diet (MedDiet) and the practical application of the principles of this diet.<br/><br/><b>Materia...
In vitro antifungal activity of new thiatriazole derivative agents
Purpose: The assessment of the antifungal activity of 59 new synthesized compounds. We compared the antifungal activity of N,N-phenyl-1,2,3,4-thiatriazole-5-yl-2,4-b-resorcyl-carbothioamide (PTR), of n-3-(1,2,4-dithiazol...