Benign, Multicentric, Recurrent and Metastasizing Giant Cell Tumor of Bone: Review of Literature with Role of Immunohistochemistry in Determining Prognosis
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 7
Abstract
Objective: Giant cell tumor (GCT) represents around 4-5% of all primary bone tumors. The purpose of this article is to report this unusual case of benign metastasizing GCT and simultaneously emphasize on the role of immunomarkers in predicting the aggressive behaviour of such lesions and a brief review of literature along with the proposed management strategies in these patients. Case: We report a rare case of benign GCT in a 24 years old Asian female. Initial presentation of the disease was 9 years back with involvement of lower end of right humerus; development of a multicentric lesion in right 4th metacarpal 2 years after the humerus lesion, and elbow tumor recurrence after 6 years. In all instances en-block tumor resection with bone grafting was performed. Now, the patient presented to us with recurrent tumor at both sites; radiological types 2&3 lesions, local lymphatic involvement and metastatic nodules in bilateral upper pulmonary lobes. Right shoulder disarticulation with biopsy of pulmonary metastases was performed. Histopathology revealed a benign GCT morphology. Immunohistochemistry for Ki67 showed higher expression, while p53 showed negative staining. Conclusion: GCT is still one of the most obscure and intensively examined tumors of bone. Histology does not predict the clinical outcome & few studies have been performed to identify new markers predictive of aggressive behaviour. A relationship between increased proliferative rate (higher Ki67 expression) and possibility of recurrence has been found. Few pilot studies have demonstrated correlation of p53 mutation with local recurrence and malignant transformation.
Authors and Affiliations
Anshu Jain
Keywords
Related Articles
- EP ID EP212238
- DOI -
- Views 97
- Downloads 0
Predisposing Factors for Pulmonary Tuberculosis
Aim of The Work: This study was intended to elucidate the role of different risk factors in the development of pulmonary tuberculosis in our locality in order to avoid exposure to possible risk factors, controlling possi...
Comparative Study of Serum Testosterone Levels in Male Patients of Type 2 Diabetes Mellites and Non Diabetics Presenting with Complaints of Sexual Dysfunction
Background: Diabetes mellitus is the frequent cause of sexual dysfunction in males. Various studies have reported 25 – 32 % of men with Diabetes mellites complaining of sexual dysfunction. Material and Methods: This was...
Role of Real Time PCR in Detection of MTB, MDR and XDR TB Directly from Sputum Specimens of Clinical Suspects of PTB
Background and Objectives: “Presently, Sikkim has emerged as the next big concern on India’s already riddled tuberculosis map with 11 per cent of the new tuberculosis cases in the State found to be multi-drugresistant”;...
To assess awareness regarding Diabetes Mellitus and factors affecting, in a tertiary care teaching hospital of Agra
Introduction: It is important to know about the awareness level of a disease condition in a population, which plays a vitole role in future development, early detection and prevention of disease. Objective: To Assess awa...
Comparison between manual liquid based cytology and conventional Pap smear for evaluation of cervical lesions and it’s histopathological correlation in cases of epithelial abnormalities
Introduction: Pap smear has been most widely used screening method for cervical cytology since last 50 years. Despite of it reducing morbidity and mortality from cervical cancer by detecting precancerous lesions, false n...