Biochemical and Clinical Variables of Normal Parathyroid and Hyperparathyroid Diabetic Chronic Kidney Disease Patients

Journal Title: Journal of Enam Meical College - Year 2016, Vol 6, Issue 3

Abstract

Background: In chronic kidney disease (CKD) intact parathyroid hormone (iPTH) level is often increased before clinical hyperphosphatemia occurs. Despite its importance very few studies evaluated parathyroid status in CKD. Objective: The study was undertaken to estimate level of parathormone in diabetic CKD patients at a tertiary level hospital and assessing its relationship with different parameters like hemoglobin, calcium etc. and comparing biochemical and clinical variables between normal parathyroid and hyperparathyroid groups. Materials and Methods: It was a hospital based cross-sectional study involving purposively selected chronic kidney disease patients attending nephrology and endocrinology outdoor and indoor services of BIRDEM hospital, Dhaka, Bangladesh. Study was conducted during the period of April to October 2010. All the subjects were divided into two groups based on serum parathormone level and different parameters were compared between groups. Results: The mean duration of chronic kidney disease was significantly higher in hyperparathyroid group than that in the normal group (<0.001). Retinopathy and hypertension were more common in hyperparathyroid group than that in patients with normal serum parathormone (p<0.001 and p=0.012). Neuropathy was solely present in hyperparathyroid group (p<0.001). Mean fasting blood glucose, serum creatinine and serum phosphate were significantly higher in the hyperparathyroid group compared to normal group (p<0.001 in all cases) while the mean serum calcium and haemoglobin were lower in hyperparathyroid group than those in the normal group (p<0.001 in both cases). Serum creatinine and serum parathormone bears a significantly linear relationship (r=0.986, p<0.001), while serum parathormone and serum calcium bears a significantly negative relationship (r=?0.892 and p<0.001). Conclusion: Earlier intervention on the basis of iPTH in addition to other biochemical parameters of chronic kidney disease is recommended.

Authors and Affiliations

Syed Abdul Kader, Faruque Pathan, Md Ruhul Amin, Md Azizul Hoque, Sonia Afrin Rob

Keywords

Related Articles

Barriers to Exclusive Breastfeeding among Urban Mothers

Background: Breastfeeding is the unique source of nutrition and it plays an important role in the growth, development and survival of the infants. The initiation of breastfeeding within one hour and continuation of onl...

Acute Limb Ischemia in a 95-year-old Female

plaques in aorta, mainly in the infrarenal segment, the aorta was patent up to its bifurcation. Aboveknee amputation was done on following day after admission with subsequent disarticulation. Acute limb ischemia is a...

Biochemical and Clinical Variables of Normal Parathyroid and Hyperparathyroid Diabetic Chronic Kidney Disease Patients

Background: In chronic kidney disease (CKD) intact parathyroid hormone (iPTH) level is often increased before clinical hyperphosphatemia occurs. Despite its importance very few studies evaluated parathyroid status in CKD...

Helicobacter Pylori Eradication Therapy in both Erosive and Non-erosive Gastritis — A Prospective Study

Background: Infection with Helicobacter pylori (H. pylori) is a recognized cause of peptic ulcer and gastritis. Persistence of infection is a definite risk factor for gastric malignancy. Healing of gastritis after erad...

Asymptomatic Hydatid Cyst in a 30-year-old Female

A 30-year-old female presented in the outpatient department of Orthopedics with the history of low backache for 1 month. Physical examination revealed normal findings. A plain radiography of lumbo-sacral spine showed...

Download PDF file
  • EP ID EP36274
  • DOI https://doi.org/10.3329/jemc.v6i3.29680
  • Views 325
  • Downloads 0

How To Cite

Syed Abdul Kader, Faruque Pathan, Md Ruhul Amin, Md Azizul Hoque, Sonia Afrin Rob (2016). Biochemical and Clinical Variables of Normal Parathyroid and Hyperparathyroid Diabetic Chronic Kidney Disease Patients. Journal of Enam Meical College, 6(3), -. https://www.europub.co.uk/articles/-A-36274