Biochemical and Haematological Profile in Patients with Alcohol Dependence Syndrome (ADS) Co-Morbid with Nicotine Dependence Syndrome (NDS)
Journal Title: International Journal of Biochemistry Research & Review - Year 2016, Vol 13, Issue 4
Abstract
Aims: To compare and assess the biochemical and haematological parameters in patients with Alcohol dependent syndrome (ADS) co-morbid with Nicotine dependent syndrome (NDS) in comparison to those with only Alcohol dependent syndrome (ADS). Study Design: Observational case control study. Place and Duration of Study: Department of Biochemistry and Department of Psychiatry, Vailankanni Deaddiction centre, Father Muller Medical College, Mangalore. Methodology: The subjects consisted of 30 male patients (age range 27-64 years) with Alcohol dependent syndrome co-morbid with Nicotine dependent syndrome (ADS+NDS), 30 male patients (age range 26-60 years) with Alcohol dependent syndrome (ADS) and 30 male normal healthy volunteers (age range 28-46 years). Activities of liver function marker enzymes and levels of haematological parameters were assayed by standard methods. Results: Activities of alanine aminotransferases(ALT), aspartate aminotransferases(AST), alkaline phosphatase(ALP) and gamma glutamyl transferase(ƔGT) were significantly higher in patients with ADS+NDS and only ADS, in comparison to healthy controls (p< .001). The haemoglobin, RBC counts, polymorphonuclear cells were significantly decreased in only ADS group compared to controls (p< .01) and MCV and ESR were significantly increased in patients with ADS+NDS and only ADS (p<0.001). No significant difference was observed between patients with ADS+NDS and only ADS, with respect to biochemical and haematological parameters. There was significant correlation of ƔGT with ALT(r=0.72) and AST(r=0.88) in only ADS group and ALT with AST(r=0.79; r=0.83) in both ADS+NDS and ADS groups. Conclusions: Significant changes were evident in biochemical and haematological parameters in patients with only Alcohol dependent syndrome. These parameters could serve as markers of alcoholism.
Authors and Affiliations
J. B. Honnamurthy, A. R. Shivashankara, P. John Mathai, M. Malathi
Keywords
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- EP ID EP351175
- DOI 10.9734/IJBCRR/2016/29038
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