BIOCHEMICAL STUDY ON THE REGENERATIVE EFFECT OF BEE VENOM ON EXPERIMENTALLY INDUCED DIABETES
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 10
Abstract
In the present study, the potential therapeutic effect of bee venom administration diabetic rats was evaluated. Thirty male albino rats were divided into three equal groups of 10 rats each. Group Ι:(Control group): received no drugs. Group II:(Diabetic rats group): rats received a single dose of Streptozotocin (STZ) (50- mg/kg-b.wt i.p). Group III:(Diabetic rats + bee venom treated group): rats are treated with + bee venom 0.5 mg /kg body weight /day, i.p) for 21 days after diabetes induction. Blood samples and pancreatic tissue were collected at the 22th day from the onset of bee venom administration. The obtained results showed that, STZ-induced diabetic rats exhibited a significant increase in serum glucose, triglycerides, total cholesterol, LDL-cholesterol, malondialdehyde (MDA), advanced glycation end products (AGEs) and glycated hemoglobin (HbA1c) with marked decrease in HDL-cholesterol, insulin levels, Catalase (CAT), glutathione peroxidase (GSH-px), superoxide dismutase (SOD). Treatment with bee venom was able to mitigate diabetic abnormalities through decreasing serum glucose, triacylglycerols, total cholesterol, LDL-cholesterol, malondialdehyde (MDA), advanced glycation end products (AGEs) and glycated hemoglobin (HbA1c) and increasing HDL-cholesterol, insulin levels, Catalase (CAT), glutathione peroxidease (GSH-px) and superoxide dismutase (SOD), These results suggest that bee venom are effective in increasing insulin sensitivity and secretion in diabetic rats and improving other biochemical blood parameters.
Authors and Affiliations
Dr. Mohamed A. M. Ali
Keywords
Related Articles
- EP ID EP628054
- DOI -
- Views 160
- Downloads 0
CLINICAL TREATMENT OUTCOMES OF PNEUMONIA AMONG HOSPITALIZED PEDIATRIC PATIENTS IN NEKEMTE REFERRAL HOSPITAL, PEDIATRICS WARD, ETHIOPIA
Introduction: In Ethiopia, pneumonia is the most common cause of morbidity and mortality in pediatric population. Regardless of improved coverage of preventive interventions, approximately 4 million childhood pneumonia c...
CRITICAL REVIEW OF ANUKTA DRAVYA “LAHSUN BEL (MANSOA ALLIACEA)
Medicinal plants are scientifically documented in Ayurvedic literature based on the sound fundamentals of rasa (Taste), guna (Property), virya (Potency), vipaka (Metabolism) and prabhava (Specific action).Vedic to Samhit...
CLINICAL, HISTOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF MALIGNANT BRENNER TUMORS OF OVARII. REVIEW AND CASE REPORT
Brenner Tumor (BT) is a relatively uncommon neoplasm, accounting 1- 2% of all ovarian neoplasms, identified in 1907 by Fritz Brenner. Most BTs are benign. Malignant BTs are extremely rare, comprising < 5 % of all ovarian...
RECENT ADVANCEMENT IN DRUG DELIVERY SYSTEM FOR BRAIN: AN OVERVIEW
The brain is one of the most complex and magnificent organs in the human body. It is the organ that controls most of the activities of the body. The central nervous system [CNS], efficiently isolated from the systemic ci...
PAEONOL AND QUERCITRIN, ACTIVE COMPONENTS OF XIANGQING ANODYNE SPRAY, SYNERGISTICALLY IMPLEMENT ANTI-INFLAMMATORY EFFECTS BY SUPPRESSING P38, ERK, AND AKT SIGNALING PATHWAYS
Background: Previously, we revealed that Xiangqing anodyne spray (XQAS), a traditional Chinese medicine formulation, significantly decrease acute soft-tissue injury by suppressing p38 and AKT activation. Here, we clarifi...