BIOLOGICAL ACTIVITY OF CHLORINATED COMPOUNDS AND INTERMOLECULAR INTERACTIONS
Journal Title: Journal of Biological and Scientific Opinion - Year 2013, Vol 1, Issue 1
Abstract
Biological activity of chlorinated compounds has been analyzed in relation to their electron parameters. It is established that the toxic and narcotic actions chlorinated chemical compounds due to their ability to intermolecular interactions. General regression equations are given for electron parameter – dependent changes in the bioactivity of molecules. Statistical comparison of qualitative indexes has revealed that the energetic parameters of the molecules that define the intermolecular interactions are the most informative characteristics of the chlorinated compounds responsible for the toxicity and narcotic effects. Molecular mechanisms of the toxic effect of chlorinated compounds are discussed in terms of intermolecular interactions. It is discussed the influence on bioactivity of the formation donor – acceptor complexes and hydrogen bonds.
Authors and Affiliations
V K Mukhomorov
Keywords
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- EP ID EP125777
- DOI 10.7897/2321-6328.01123
- Views 145
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