Biomarkers for Early Detection of Hypertensive Disorders in Pregnancy: Current Applications and Future Directions- The Role of Extracellular Matrix
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 16, Issue 2
Abstract
Hypertensive disorders in pregnancy (HDP) are the most common medical complications, affecting 5–10% of pregnancies worldwide. Their early detection is critical for risk stratification and prevention of further pregnancy complications. Despite current intensive search of biomarkers for early detection and prognosis of HDP, the clinical efficacy of these markers has shown low predictive value. There is a growing evidence for extracellular matrix involvement in HDP’s pathophysiology. Clinicians need better tools for predicting HDP. Biomarkers of extracellular matrix turnover are one of the possible candidates.Hypertension is the most common medical problem encountered during pregnancy, complicating 2-3% of pregnancies. Hypertension in pregnancy is not a single entity but comprises preexisting hypertension, gestational hypertension, pre-eclampsia, pre-existing hypertension plus superimposed gestational hypertension with proteinuria and antenatally unclassifiable hypertension [1]. Preeclampsia (PE) is a disease, which has not been fully studied yet. It is a major cause of maternal and perinatal morbidity and mortality [2]. Preeclampsia is a prevalent and ambigous disease, in part characterized by poor remodelling of the spiral arteries. However, preeclampsia does not always clinically present when remodelling has failed to occur [3].
Authors and Affiliations
N Popovski, A Nikolov
Keywords
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- EP ID EP585483
- DOI 10.26717/BJSTR.2019.16.002816
- Views 189
- Downloads 0
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