Biosurfactant As the Next Antimicrobial Agents in Pharmaceutical Applications
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 13, Issue 3
Abstract
The number of patients with antimicrobial resistance is growing as a result of new emerging microbes or overuse of antibiotics. A new substitute to the existing antimicrobial agents is important in time to come to control the mortality rate in the global population. Natural substances, like biosurfactants or commonly known as microbial surfactants could be a potential antimicrobial agent to medical personnel’s consideration as some biosurfactants exhibits antimicrobial activity. Hence, this paper will briefly highlight some of the findings from contemporary researchers who have tested different biosurfactants for potential antimicrobial activity.According to World Health Organization (WHO), 2014 [1] report antimicrobial resistance is one of the biggest health problems faced globally. Mortality rate due to antibiotic resistance has become unstoppable like the globalization force. As the world is growing with technology newer microbial species are emerging as a result of antigenic drift due to random mutation and leading to fatality. On another note unnecessary antibiotic prescription too has a huge contribution towards the microbial resistance as this causes the body to build up resistance to the prescribed drugs. Thus, antibiotics becomes ineffective. Pneumonia, tuberculosis, blood poisoning and foodborne diseases are some of the reported growing infectious diseases globally [1]. The mentioned disease requires a serious attention and need to be treated soon to prevent its impact on our life expectancy. Food safety factsheet by WHO reported that over 500 million people became sick and approximately 230 000 deaths were recorded from diarrheal diseases that resulted from food poisoning. In a common man’s book food poisoning is a normal disease and can be treated with antibiotics. Unfortunately, they are unaware of the bitter truth that the common bacteria like Staphylococcus aureus, Escherichia coli, Salmonella, Campylobacter and Vibrio cholerae classified as foodborne bacteria are becoming resistant to the available antibiotics these days [2,3] Likewise, number of deaths for tuberculosis in the past 5 years is at its alarming rate where over 10 million deaths were recorded worldwide outnumbering HIV/AIDS deaths [4]. It seems like controlling the spread of this single infectious agent, Mycobacterium tuberculosis is a big challenge with the existing antibiotics [5]. Not to deny that all this scenario and case reports fears the medical officers on what is going to happen to the human population if the current antibiotics resistance continues to escalate and what other alternatives to control the microbial colonization and spreading in patients. This paper seeks to remedy this problem by analysing literatures on biosurfactant as an optional antimicrobial substitute to counter the current antimicrobial resistance.
Authors and Affiliations
Sumathy Vello, Parveen Jamal, Zahangir Alam, Mohammed SJ, Noor Bin S, Wan Mohd Fazli WN
Keywords
Related Articles
- EP ID EP585821
- DOI 10.26717/BJSTR.2019.13.002394
- Views 152
- Downloads 0
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