Bis-Schiff Bases of Isatins: A New Class of Antioxidant
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 10
Abstract
Twenty seven (27) derivatives of bis-Schiff bases of isatins 1-27 were screened for their antioxidant potential. Out of twenty seven (27), four compounds exhibited a varying degree of superoxide anion radical scavenging activity with IC 50 values ranging between 156.34 - 273.15 µM. Compounds 7 ( IC 50 = 156.34 ± 0.22 µM), 9 ( IC 50 = 273.15 ± 1.60 µM), 13 ( IC 50 = 224.12 ± 0.80 µM), and 16 ( IC 50 = 225.03 ± 0.73 µM) showed a good superoxide anion radical scavenging activity, when compared to standard n-propyl gallate (IC 50 = 104.04 ± 1.70 µM). However, compounds 3 and 7 exhibited DPPH radical scavenging activity with IC 50 values 436.90 ± 0.59, 46.63 ± 0.26 µM, respectively.
Authors and Affiliations
Khal id Mohammed Khan, a Momi n Kh a n , a Ni d a Amb r e e n , a F a z a l Ra h im, a Bakht iar Muhammad, c S a j j
Keywords
Related Articles
- EP ID EP86646
- DOI -
- Views 117
- Downloads 0
Formulation and Evaluation of Mesalamine Microspheres for Colon Targeted Drug Delivery System
Mesalamine (5-ASA) is an anti-inflammatory drug used in treatment of Crohn’sdisease and ulcerative-colitis. As Mesalamine is rapidly absorbed from the small intestine and it is necessary to develop a colon-specific deliv...
In vitro evaluation of free radical scavenging activity of medicinal plant Polyalthia longifolia (Sonner.) Thw. leaf extract
The present study was aimed at investigating the antioxidant activities of the ethanol and chloroform extracts of the leaves of Polyalthia longifolia (Sonner.) Thw. (Annonaceae). The antioxidant activities of the extrac...
Benzimidazole compounds: As antimicrobial agents
Heterocyclic compounds exhibited remarkable pharmacological activities. Literature indicates that compounds of pyrimidine, pyridine, benzimidazole nucleus have wide range of therapeutic uses such as antitubercular, anti...
Antifungal Activity and Phytochemical Analysis of Aqueous Extracts of Ricinus communis and Punica granatum
In the present investigation, the aqueous leaf and pericarp extracts of castor oil plant (Ricinus communis) and pomegranate (Punica granatum) were evaluated for antifungal activity against Candida species and subsequentl...
Emergence of ‘Super Bug’ and Use of Antibiotics: What We Learned, What We Have Yet to Learn?
Recent reports on emergence of a multidrug resistant ‘superbug’ have given the world a warning call against irrational use of antimicrobials. Few examples of most dangerous bugs include MRSA, Klebsiella Penumonia, vancom...