Blood chemistry and electrolyte analysis in Mus musculus treated with Euphorbia hirta Linn extracts
Journal Title: Journal of Ayurvedic and Herbal Medicine - Year 2016, Vol 2, Issue 3
Abstract
Euphorbia hirta’s effects on the blood chemistry in albino mice (Mus musculus) had been investigated in this study. There were 15 mice per gender (10 experimental, 5 control). 0.5 mL of the 1:10 g:mL decoction was administered after 40 days of acclimatization. Approximately 2 hours after the oral administration of the extract, 0.5 mL of blood was obtained through intracardiac extraction. Laboratory tests showed that in males, only K showed significant decrease and none in females (p=0.001). Analyses on the degree variation between male and female, significant changes were observed to have occurred in their levels of creatinine, blood urea nitrogen, and uric acid (p=0.048, 0.035, 0.006, respectively). Highest electrolyte decrease was male’s K (26.5%), and female’s UA for blood chemistry (30.1%), while highest increase in males’ Na and females’ BUN was observed (7.9% and 25.5%, respectively). It is then hypothesized that hormones may play in the blood chemistry and not much in the electrolytes. Further, it could also be that the extracted molecules do not react on individual molecules, rather than more complicated molecules such as those in the blood chemistry. Using other extracting method and longer periods of extract administration can be considered for further investigation.
Authors and Affiliations
Edward Laurence L. Opena
Keywords
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