Blood Sugar & Vitamin B12 Level in Psoriasis Patients in Relation to Diabetes Mellitus and Hyper Tension
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 4
Abstract
Background: Psoriasis is a chronic disfiguring inflammatory and proliferative condition of the skin in which both genetic and environmental influences have a critical role. Several reports have shown an increased risk for the metabolic syndrome (a combination of central obesity, DM Type 2 or insulin resistance, Hyper Tension and combined hyperlipidemia) in patients with psoriasis, but there are few Indian studies on the association between psoriasis with diabetes and hypertension together. Objective: To study blood sugar and serum B12 level at the beginning of study and after 8 weeks in 2 groups of Psoriasis patients. Method: A cross-sectional study was performed in 300 clinically diagnosed Psoriasis patients (Group II) which were further grouped as 200 plain psoriasis (Group IIA) and 100 psoriasis cases with DM or DM and HT both (Group IIB) and 200 age and gender matched healthy subjects as the controls(Group I). Blood sugar and serum Vit. B12 level were measured at the beginning of study and after 8 weeks in both the groups. Result: Patient presented no significant change in the blood glucose level in Group IIA psoriasis patients at the beginning of study and after 8 weeks as compared to controls but in Group IIB psoriasis there is significant increase (P<0.01) at the beginning but after 8 weeks its value is increased highly significantly (P<0.001) as compared to controls. Serum B12 level is decreased and increased significantly (P<0.01) in Group IIA psoriasis patients at the beginning and after 8 weeks respectively. But in Group IIB psoriasis patients its value is decreased and increased highly significantly (P<0.001)at the beginning of study and after 8 weeks which shows that B12 level is lower in psoriatic skin than in non-psoriatic skin and active lesions had lower level than healed lesions. Conclusion: Data suggests that psoriatic patients must be considered as a group at high risk for becoming diabetic due to high Blood sugar level and more prone for cardiovascular disease due to low serum B12 level in psoriatic skin than in non-psoriatic skin.
Authors and Affiliations
Payasvi Baweja
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