Breast cancer risk associated with being treated for infertility: results fromthe French E3N cohort study.
Journal Title: Human Reproduction (Oxford) - Year 2004, Vol 19, Issue 10
Abstract
BACKGROUND: The use of fertility drugs (FDs) is steadily increasing inWestern countries and concern has been raised as to the possible impact of fertility treatments on breastcancer risk. METHODS: We analysed this association in the French E3N study. In this prospective cohort,data on treatment against infertility, duration and time of administration were collected at entry throughself-administered questionnaires. Cox regression analysis was used to estimate adjusted relative risks(RRs). RESULTS: Among the 92 555 women from the study population, 6602 women were treated for infertility.During the 10 year follow-up period, 2571 cases of primary invasive breast cancer were diagnosed (183in treated women). Our study showed no overall significant association between breast cancer risk andtreatment for infertility (RR = 0.95, confidence interval 0.82-1.11), after surgery or FDs, and whateverthe type, the duration of use and the age at first use of FDs. However, infertility treatment was associatedwith an increased risk, of borderline significance, of breast cancer among women with a family historyof breast cancer. This last result had limited statistical power. CONCLUSIONS: Our study provides evidencethat treatment for infertility does not influence breast cancer risk overall. An interaction with a familialhistory of breast cancer is possible but should be investigated further.
Authors and Affiliations
X Paoletti, E Gauthier, F Clavel-Chapelon
Keywords
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