Caffeine and Cannabis Effects on the Cerebellar Cortex of Juvenile Rats
Journal Title: Journal of Advances in Biology & Biotechnology - Year 2017, Vol 15, Issue 3
Abstract
Caffeine and cannabis are two of the world most popularly consumed psychoactive substances. While caffeine is consumed with little or no regulation and restrictions in moist of the countries of the world; cannabis safety of consumption has been queried severally and as such, it is labeled an illegal drug in many countries. It is important to appreciate what the effects of these two substances could be especially in juvenile models with an attempt to mimic the real life scenarios where several people consume these drugs as teenagers and adolescents. To this end, 72 juvenile Wistar rats were distributed into six groups labeled A-E. Group A served as the control and the animals were only fed ad libitum; Group B were administered the lower dosage of caffeine; Group C were administered the higher dosages of caffeine; Group D were administered the lower dosage of cannabis; Group E were administered the higher dosage of cannabis while the Group F were administered the both caffeine and cannabis- each substance being the lower dosage. The administration lasted 21 days and the animals were sacrificed thereafter. The cerebellum was excised in each animal; fixed in formal saline and then processed using the Haematoxyline and Eosin staining technique to observe the histological structures of the tissues. Results were taken in forms of photomicrographs, and analysed. Observations show that the higher doses of the agents used had effects that could be deleterious on the cerebellar architecture, especially by morphologically distorting the Purkinje cells.
Authors and Affiliations
J. O. Owolabi, S. Y. Olatunji, A. J. Olanrewaju, P. U. Abu
Keywords
Related Articles
- EP ID EP318183
- DOI 10.9734/JABB/2017/36943
- Views 109
- Downloads 0
In Silico Analysis and Comparison of Alpha Tubulin Gene with Other Tubulin Families
Microtubules are composed of a heterodimer of alpha and beta tubulins and performs many diverse functions. The genes encoding these microtubule constituents are members of the tubulin superfamily. Studies shown the exist...
Antibiotics Susceptibility Profile of Listeria Species Isolated from Poultry Wastes and Fishpond Water from Private and Institutional Farms in Ibadan, Nigeria
Introduction: Untreated waste being discharged into the environment due to proliferation of poultry and fish farms can constitute a public health threat to human. Listeria, an emerging pathogen is commonly associated wit...
Mucosal Opened Cavities as the Organ of Increased Resistance and Effectiveness
New aspects of human mucosal cavity protection systems are under consideration. On the basis of own data it was suggested that mucosal cavities function as mucosal organs. New players of mucosal organ were proposed. They...
Evolution of Lipid Oxidation in Syrian Olive Oil under Irradiation and Storage
Aims: The current study examines variations in Syrian olive oil (SOO) after gamma irradiation treatment and during storage. Study Design: Four irradiation treatments (0, 1, 2 and 3 kGy) were distributed in a completely...
Partial Purification and Characterization of Angiotensin Converting Enzyme Inhibitory Alkaloids and Flavonoids from the Leaves and Seeds of Moringa oleifera
Aim: In the present study, the alkaloid, flavonoid and saponin-rich extracts of the leaves and seeds of Moringa oleifera were partially-purified and the ACE inhibitory activities and patterns of inhibition determined. Me...