Can IV Infusions of Bone Marrow Derived Mesenchymal Stem Cell Extracellular Vesicles be the Fountain of Youth?
Journal Title: Journal of Regenerative Biology and Medicine - Year 2019, Vol 1, Issue 2
Abstract
There is increasing published literature to support the safety and efficacy of IV infusions of bone marrow-derived expanded allogeneic mesenchymal stem cells (MSCs) for the treatment of various auto-immune diseases. Frailty Syndrome was created to provide a way of objectively measuring aging with physical activity scales and bio-inflammatory markers. IV infusions of allogeneic MSCs have been reported to statistically significantly increase physical function and decrease inflammatory biomarkers in Frailty Syndrome. Replacing cellular allogeneic IV infusions with acellular bone marrow-derived MSC extracellular vesicle isolate products (EVIP) containing active growth factors (GFs) and exosomes has numerous advantages. Regenerative medicine researchers and clinicians now realize that living MSCs are not required to achieve clinical efficacy. The clinical efficacy of MSCs is due to their paracrine release of GFs and exosomes. Living MSCs are not required to accomplish the paracrine signaling of GFs and exosomes. Acellular MSC EVIP containing active GFs and exosomes are the future of regenerative medicine. Acellular exosomes derived from bone marrow MSCs provide a consistent product that has extensive characterization, which includes advanced particle analysis, proteomic evaluation and USP<71> sterility assurance. The future “Fountain of Youth†will be the frequent (3 to 4 times per year) IV infusion of bio pharmacologic quality bone marrow-derived MSC EVIP. These active GF and exosome infusions will result in a continual down regulation of systemic inflammation and based on published research reverse many of the inflammatory effects of aging.
Authors and Affiliations
Johnny East DO and Maxwell Dordevic*
Keywords
Related Articles
- EP ID EP707313
- DOI https://doi.org/10.37191/Mapsci-2582-385X-1(2)-010
- Views 108
- Downloads 0
The Importance of Four-Finger Furrow in the Diagnosis of Pediatric Chromosomal Anomalies
Since Langdon-Down in 1909 paid special attention to the special formation among the flexion furrows of the human hand, generally known as Affenfurche or Vierfingerfurche, in connection with the clinical picture of mongo...
Aberfan: In memoriam
It was an ordinary day in Aberfan, Wales, and it ended in a disaster. On October 21, 1966, a 34-meter-high slag heap broke loose, slid down Mount Merthyr into the mining village and buried houses and an elementary school...
Case Series: Use of Coralline Hydroxyapatite Graft in Faciomaxillary Surgery
Bone grafting represents an important solution for defects in maxillofacial and orthopaedic surgeries. Ideal properties of a bone graft allow proper integration, enabling cosmetic appeal and mechanical functionality. Whi...
Parkinson’s Disease-Overview
Parkinson’s disease one of the most complex neurological disorder. The disease risk and progression are due to common genetic variants. Approximately 6.2 million cases are reported each year according to the statistics p...
Cardiology Clinic in COVID-19 Era Review Article
The outbreak of COVID-19 and succeeding lockdown curtailment of routine life activities resulted in a profound effect on healthcare systems, globally. There were difficulties in Outpatient follow-up during this time. Sin...