CANCER OF UNKNOWN PRIMARY SITE SYNDROME- CUP SYNDROME - DIAGNOSTIC AND THERAPEUTICAL DILLEMAS
Journal Title: Acta Facultatis Medicae Naissensis - Year 2014, Vol 31, Issue 2
Abstract
Metastatic carcinomas of unknown primary origin (cancer of unknown primary-CUP) represent 3-5% of all cancers. This term includes all patients presented with metastatic disease in whom the primary site could not have been identified. Despite the use of modern and comprehensive diagnostic techniques and procedures, there is no improvement in efficacy (efficiency) of indentifying the primary site of disseminated disease. That is why a diagnostic procedure should be rational and should include the basic diagnostic examination (analyses) with the aim to define biological and clinical characteristics of diagnosed disease, as well as an optimal therapeutic approach. Although the overall prognosis of the majority of these patients is poor, it is possible, nowadays, to distinguish the subgroups of patients with favorable prognosis. Results of new basic research, better understanding of pathogenesis at the molecular level and introduction of new drugs through clinical trials suggest an advance in this disease treatment and outcome. Key words: malignant tumor, metastases, chemotherapy, CUP
Authors and Affiliations
Ivica Pejčić, Svetislav Vrbić, Mirjana Todorović, Ivan Petković, Ana Stanković
Keywords
Related Articles
- EP ID EP126528
- DOI 10.2478/afmnai-2014-0010
- Views 73
- Downloads 0
VALUE OF THE FIRST EXAMINATION FOR DEVELOPMENTAL DYSPLASIA OF THE HIP - OUR EXPERIENCES
Developmental dysplasia of the hip (DDH) means a distinct dislocation (lateralisation and cranialisation) of the femoral head from the poorly developed (hypoplastic and steeper) acetabulum. The aim of the paper was to es...
KOMPARATIVNA STUDIJA O SEKSUALNOM NASILJU U TRI OBLASTI REPUBLIKE BUGARSKE U PERIODU 1997-2006
Seksualno zlostavljanje je krivično delo protiv osoba širom sveta. Bez obzira na starost žrtve, može da dovede do teških fizičkih i mentalnih posledica, zloupotrebe droga i psihoaktivnih supstanci, reproduktivnih teškoća...
Erythropoietin Resistance in Hemodialysis Patients
Anemia is defined as blood hemoglobin concentration of less than 120 g/l in women and less than 130 g/l in men. The main cause of the development of anemia in patients treated with regular hemodialysis is the lack of end...
INTERNET-BASED PROMOTION OF SAFER SEX AND CONDOM USE AMONG YOUNG PEOPLE
Sex education is aimed at equipping individuals with sex-related information, motivation, and behavioral skills that will enable them to avoid sex-related problems and to achieve sexual well-being. Safer sex promotion an...
KLINIČKA KOMPARACIJA KVALITETA ZALIVANJA FISURA FISURALâ-om I IONOSITâ-SEAL-om U OPSERVACIONOM INTERVALU DO DVE GODINE
Postoji gotovo jedinstveno mišljenje da je fisurni sistem "područje osetljivo na karijes". Ove poteškoće navele su na razmišljanje o efikasnoj zaštiti fisurnog sistema od karijesa. Za finalnu realizaciju ove metode neoph...