Cancer Stem- Like Cells in Melanoma Progression, Resistance and Recurrence: Significance for Melanoma Treatment
Journal Title: International Journal of Stem Cell Research and Transplantation (IJST) - Year 2014, Vol 2, Issue 4
Abstract
Human malignant melanoma is a highly aggressive tumor which demonstrates heterogeneity and a propensity to drug resistance. Despite improved treatment options, patients with advanced malignant melanoma continue have a poor prognosis as measured by progression-free and overall survival. The cancer stem-like cell (CSC) hypothesis suggests that neoplastic clones are maintained by a small fraction of cells with stem cell properties. As has been demonstrated with other tumor types, melanoma progression, resistance to chemo- and radiotherapy, and recurrence can be attributed to a small fraction of cells termed melanoma stem-like cells (MSCs). These MSCs are characterized by a distinct protein patterns and aberrant signaling pathways, which are either in a causal or consequential relationship to tumor progression, drug resistance and recurrence. This review focuses on the mechanistic role of MSCs leading to tumor progression and metastasis, resistance and recurrence. Understanding the molecular mechanisms underlying MSCs migration, invasion, resistance to standard treatments, and recurrence may help to improve current therapeutic modalities and/or pave the way for the development of new therapeutical management strategy for tumor treatment.
Authors and Affiliations
Mohamed Hassan
Keywords
Related Articles
- EP ID EP195234
- DOI 10.19070/2328-3548-1400013
- Views 115
- Downloads 0
Protective Role of Bone Marrow Derived Mesenchymal Stem Cells-Conditioned Medium in the Infarcted Myocardium: The Potential Role of Selected Cytokines
This study examines the protective effects of mesenchymal stem cell-conditioned (CM) medium on heart tissue after induced myocardial infarction (MI). New Zealand White Rabbits were divided: MI, mesenchymal stem cells (MS...
Neonatal Eye Defects and Stem Cell Therapeutics
Present review aims to describe various neonatal eye defects and its stem cell therapeutics. This article attempts to highlight common causes of visual impairment in infants and present the recent approaches used for res...
Tolerance in Organ Transplantation: Evolution of Strategies
Tolerance in Organ Transplantation: Evolution of Strategies
Effects of 5-Azacytidine on Differentiation of Ovine Mesenchymal Stem Cells
Background: Mesenchymal stem cells (MSCs) have potential of self-renewal and differentiation into many cell types and can be used for cells therapy. Addition of epigenetic drugs can also convert these cells into cardiomy...
Side Population Cells in Human Adenomyotic Lesions Display Characteristics of Endometrial Stem Cells
Introduction: The precise etiology and physiopathology of ademyosis is still unknown. The aim of this research is to investigate if stem cells are found in adenomyosis and to characterize the role of adenomyotic lesion-d...