Candidemia in Non-Neutropaenic Patients in a Tertiary Care Centre in South Kerala
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 1
Abstract
Blood stream infections due to candida species cause significant morbidity and mortality especially in the nosocomial setting. The infection is common among the Immuno compromised patients. But it is rare in healthy and non-neutropaenic patients. Systemic candidiasis is an opportune mycosis caused by candida species. Acute disseminated candidiasis usually presents as candidemia. Blood cultures positive for candida species must never be ignored. Surveillance for candidemia is necessary to detect the species distribution and antifungal resistance. A 2 year study was conducted in the department of Microbiology, Govt. Medical College, Thiruvananthapuram, Kerala to find out the prevalence of candidemia among non – neutropaenic patients admitted in the medical wards and intensive care units of the Govt. Medical College Hospital, Thiruvananthapuram. A total number of 4192 blood samples were screened for candida species of which 13 samples yielded candida species in culture. Among the isolates, candida albicans was the predominant species (53.84%) followed by candida tropicalis (15.38%) candida parapsilosis (15.38%) candida glabrata (7.69%) and candida krusei (7.69%). Patients were treated with 3 different antifungal agents – Amphotericin B, Fluconazole and voriconazole. The efficacy of voriconazole was found to be 100%. The mortality rate was 23.08% in this study which is significantly reduced when compared to many other studies which may be due to prompt diagnosis and effective management with appropriate antifungal therapy.
Authors and Affiliations
Dr. Lancy J.
Keywords
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