Captopril fast disintegrating tablets for children: formulation and quality control by HPLC
Journal Title: Trends in Pharmaceutical Sciences - Year 2017, Vol 3, Issue 3
Abstract
Captopril is an angiotensin converting enzyme inhibitor, which is used in hypertensive crises and heart failures as an emergency medication especially in pediatrics. Due to difficulty in swallowing of tablets and capsules, pediatric compliance for medication usage is a big challenge in formulation. Considering captopril instability in oral liquid media, it should be formulated as a solid dosage form. Using fast disintegrating tablets (FDTs) is an attractive strategy for solving this problem. According to captopril ultra violet absorption spectrum, high performance liquid chromatography (HPLC) seems to be an accurate, reproducible, and precise method for analysis. Captopril HPLC method was developed and validated for linearity, accuracy, and precision. Because of captopril unacceptable taste especially for children, Eudragit E was used as a taste masking polymer to prepare granules. Crospovidon and Ac-Di-Sol were used as super-disintegrants to reduce tablet disintegration time. Flavoring agents are important ingredients in formulating FDTs for children. Different FDT formulations were prepared by direct compression and granulation-compression method. Quality test of tablets such as thickness, weight, friability, hardness, disintegration time, dissolution profile, and taste masking power were also examined. HPLC validation was confirmed by r2=0.9994, accuracy of 97.4±2.3%, and inter and intra-day precisions of 97.6±1.2 and 97.3±2.1, respectively. The optimized tablets showed suitable friability (0.85%), hardness (4.1 N), and disintegration time (40 sec) with a desirable taste related to presence of Eudragit E. An appropriate and complete dissolution profile within 30 min was also achieved. Results confirmed that captopril taste-masked FDTs would be a pleasant alternative for the available tablets in the market for using in children.
Authors and Affiliations
Shohreh Alipour, Asiyeh Mohammadi, Fatemeh Ahmadi
Keywords
Related Articles
- EP ID EP339337
- DOI -
- Views 119
- Downloads 0
Analysis of the expression level of aquaporins under acetylene treatment and pathogen attack
Fusarium wilt disease and Sigatoka leaf spots threaten global market of Musa sp. Major Intrinsic Proteins (MIP) consisting aquaporins (AQPs) facilitate the transport of water and molecules like H2O2, CO2, silicon, boron,...
Analysis of six populations of Commiphora myrrha (Nees) Engl. oleo-gum resin
True myrrh is produced by wounding the plant Commiphora myrrha (Nees) Engl. A number of oleo-gum-resins are produced from various species of Commiphora. Many of these gummy substances resemble myrrh; and sometimes are us...
A New Cost-Effective Method to Evaluate Collagenase Activity Using Nano-Graphene Oxide
Graphene oxide (nGO) is considred as a good nano carrier for enzymes to protect them in biological media against proteolytic activity and extend their activity and stability. In this paper, we reported a new inexpensive...
Comparison of docking procedures and its efficiency for Betasecretase, Aromatase and Pyruvate dehydrogenase kinase inhibitors
Proper docking protocols were presented for three known enzyme structures, human betasecretase (BACE1), Aromatase and pyruvate dehydogenase kinase (PDHK) using Autodock4.2 and Vina softwares. The validity of docking prot...
The effects of saffron consumption on lipid profile, liver enzymes, and oxidative stress in male hamsters with high fat diet
Saffron (Crocus sativus) is one of the indigenous plants of Iran. Recently its possible effects have been reported on lipid abnormalities and oxidative stress. The aim of this study was to investigate the effects of saff...