Carcinosarcoma of Breast with Hormone Receptor and Her2/neu Positivity
Journal Title: National Journal of Laboratory Medicine - Year 2016, Vol 5, Issue 1
Abstract
Carcinosarcoma is an extremely rare tumor of the breast comprising of two distinct cell lines i.e. the epithelial and mesenchymal. It is a highly aggressive tumor with a poor prognosis compared to other breast cancers with a reported incidence of less than 1% of all the breast cancers. A 35 year old female presented to surgical outpatient with a fungating mass in the right breast where cytological analysis from the affected areas revealed spindle cells of malignant potential. A modified radical mastectomy was performed and following histopathological examination of the excised tissue, a final diagnosis of carcinosarcoma of breast was concluded. Immunological staining done showed a negative staining for PR and positive staining for ER, Her-2/neu and CK receptors, as against the conventional triple negative staining pattern. Along with a rare staining pattern of this rare tumor reported in literature, this case merits presentation owing to its diagnostic and therapeutic challenges.
Authors and Affiliations
Dr. Deepti Agarwal, Dr. Vijay Malik, Dr. Ruchi Agarwal, Dr. M. K. Garg, Dr. Shilpa Garg
Keywords
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- EP ID EP378694
- DOI 10.7860/NJLM/2016/13279:2092
- Views 136
- Downloads 0
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