Caspase-1 - a role in an evolution of systemic sclerosis
Journal Title: Postępy Dermatologii i Alergologii - Year 2005, Vol 22, Issue 4
Abstract
Disturbances in the process of apoptosis are implicated among many mechanisms that may influence the development of connective tissue changes in the course of systemic sclerosis (SSc). Cysteine-aspartic acid specific proteases – caspases – are necessary for the proper course of apoptosis. One of them is caspase-1, witch plays an important role in cytokine release and development of inflammation. The aim of the study was estimation of caspase-1 serum levels in the group of 17 patients with SSc (9 with limited SSc – lSSc and 8 with diffuse SSc – dSSc) twice during one year observation and in the group of 10 healthy persons as well as evaluation of their correlation with disease activity. The patients underwent clinical examination and routine laboratory tests. Involvement of internal organs by systemic sclerosis was evaluated by relevant specialists. Antinuclear antibodies were determined by indirect immunofluorescent tests on HEp-2 cells and immunodiffusion in agarose gel. Serum levels of caspase-1 was evaluated by ELISA method with commercially available kit. The obtained results were statistically analysed. In the examined group of patients with lSSc the duration of Raynaud’s phenomenon, as well as skin sclerosis, was significantly longer in comparison to patients with dSSc (p
Authors and Affiliations
Bożena Dziankowska-Bartkowiak, Agnieszka Żebrowska, Elżbieta Dziankowska-Zaborszczyk
Keywords
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