Cellular prion level in the animals’ tissues
Journal Title: Бюлетень "Ветеринарна біотехнологія" - Year 2018, Vol 32, Issue
Abstract
Prion infections cause brain damage in humans and animals with lethal outcome. Cellular prion (PrPC) is a precursor of pathological prion. Infection development depends on the level of its production in the different tissues. Comparative data on the relative level of molecular isoforms of the cellular prion in the brain, spleen and small intestine of various animals, in particular cows, laboratory rats and mice, are demonstrated. Obtained data are important for understanding of the pathogen spreading mechanisms in the case of infection. It can be used as one of the indices for prion infection strains determination and in TSE diagnostics.
Authors and Affiliations
Maryana Kushkevych, Maria Kozak, Iryna Petruh, Basil Vlizlo
Keywords
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- EP ID EP407712
- DOI 10.31073/vet_biotech32(2)-75
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