Cerebrovascular Disease in Children with Sickle Cell Disease: Is There Any Need for Iron Therapy?
Journal Title: International Blood Research & Reviews - Year 2015, Vol 4, Issue 1
Abstract
Background: Iron deficiency is a common problem affecting children world-wide. It has been recognized to have an association with stroke. The aim of this study was to evaluate the prevalence of iron deficiency anaemia among children with sickle cell anaemia with cerebrovascular accident and the need for iron therapy. Materials and Methods: All cases of cerebrovascular disease in children with sickle cell anaemia presenting in the department of Paediatrics of the University of Teaching Hospital were prospectively investigated for serum ferritin, haemoglobin, and MCV, MCHC and blood film. Results: A total of 152 children with sickle cell disease were seen during this period. One hundred and forty nine had HbSS genotype while 3 had HbSC genotype. Cerebrovascular disease was diagnosed in 7 patients giving a prevalence rate of 4.6%. Of these, 2(28.6%) had low serum ferritin levels (P=0.09) with hypochromia and microcytosis. Conclusion: Iron deficiency anaemia is not uncommon among sickle cell patients with cerebrovascular disease. There is need for elaborate iron study in these patients so as to identify at risk cases and institute prompt treatment.
Authors and Affiliations
I. O. George, A. I. Frank-Briggs
Keywords
Related Articles
- EP ID EP242516
- DOI 10.9734/IBRR/2015/18154
- Views 132
- Downloads 0
Blood Coagulation Tests and Platelets Counts in Diabetic Rats Treated with Ficus sur, Jatropha tanjorensis, Mucuna pruriens and Chromolaena odorata Leaf Extracts
Aim: This study was designed to study the effects of leaves extracts of four indigenous Nigerian medicinal plants namely- Ficus sur, Jatropha tanjorensis, Mucuna pruriens and Chromolaena odorata on platelets counts and b...
Relationship between Glucose Level, Lipid Profiles, and Waist to Height Ratio (WHtR)
A cross sectional study was carried out to determine the relationship between glucose level, lipid profiles, and waist to height ratio (WHtR) among adults in a workplace setting. Respondents were recruited from governmen...
In vivo Studies on the Possible Haematological Changes in Rats Administered Hibiscus sabdariffa Aqueous Extract
The aqueous extract of Hibiscus sabdariffa leaves is popularly consumed in the form of “Zobo” drink in Nigeria and it is assumed to have haematological benefits. The present study was conducted to evaluate the effects of...
Serum Levels of Gamma-interferon and Interleukin-4 in Homozygous Sickle Cell Anaemia Patients
Background: Impaired leucocytes functions is among mechanisms that have been reported to account for the immunocompromised state of patients with sickle cell disease. Objective: This study assessed cellular immunity usin...
Haematological Values at Moderate Altitude in a Low-Income Population
Aim: To illustrate haematological adaptation to moderate altitude in Rwanda. Study Design: A population-based cross-sectional study. Place and Duration of Study: The study was carried out at moderate altitude (1,649-1,76...