Abstract

Surveillance of drug resistance in tuberculosis is an important component of the tuberculosis control and theraphy program. The aim of this study was to determine the susceptibilities of Mycobacterium tuberculosis complex isolates to primary antituberculosis agents and their resistance patterns. A total of 11194 samples which were sent to our laboratory for routine tuberculosis culture with the suspicion of tuberculosis clinically between 2012 and 2017 were included in the study. BACTEC MGIT 960 (BectonDickinson, USA) system was used for tuberculosis culture and susceptibility testing according to the manufacturer’s recommendations. A total of 466 (4,1%) M. tuberculosis complex were isolated from all samples and susceptibility testing was performed. 66,2%, 90,7%, 81,4%, 78%, 80%, and 74% of the M. tuberculosis complex isolates were susceptible to all primary antituberculosis agents between 2012 and 2017 respectively. The positivity of the M. tuberculosis complex was found 4,5%, 3,4%, 3,5%, 4,6%, 5,4% and 3,1% between 2012 and 2017 respectively. Resistance to at least one drug was 14,8% and multi drug resistance was 4,1%. Multi drug resistance was detected mostly in 2012. Mycobacterium other than tuberculosis was detected in 40 samples (0,4%). Monitoring of resistance patterns in tuberculosis is important in determining treatment protocols and will also be useful in preventing the development of resistance in long term.

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