Changes in circadian rhythm of prolactin in short children are dependent on growth hormone secretion
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2014, Vol 21, Issue 2
Abstract
introduction and objective. Taking into consideration the common ontogenic origin of prolactin (Prl) and growth hormone (GH), the Prl circadian pattern was analysed in children with different degrees of GH deficiency (GHD). materials and methods. The analysis comprised 100 short children (31 girls and 69 boys), aged: 10.1±3.51 years. Based on maximal GH secretion (GHmax) during two stimulating tests multiple hormone deficiency (MPHD), severe isolated GHD (SIGHD), partial isolated GHD (PIGHD) or idiopathic short stature (ISS) were diagnosed. Non-inferential chronobiometry (macroscopic analysis) of the circadian Prl rhythm, based on serum Prl measured every 3 hours during 24 hours, was performed. In this analysis, mesor, the area under curve (AUC), peak and trough level, dispersion, mean nocturnal and diurnal concentration, night/day ratio, amplitude and regression index were estimated. results. In the study group, the positive correlations between GHmax and Prl concentrations at 02:00 and at 05:00 were observed, as well as between GHmax and mesor, amplitude, mean nocturnal concentration, night/day ratio and AUC. The nocturnal rise of Prl secretion was blunted in 100% MPHD and 50% SIGHD children, whereas in most children with PIGHD and ISS, the circadian Prl rhythm was normal. conclusions. 1) In short children, the lower the concentration of GH is, the more blunted nocturnal Prl secretion becomes. 2) In the majority of MPHD and SIGHD children (but not PIGHD), the circadian Prl rhythm was disturbed; namely, reduced nocturnal Prl secretion was noticeable.
Authors and Affiliations
Renata Stawerska, Joanna Smyczyńska, Maciej Hilczer, Andrzej Lewiński
Keywords
Related Articles
- EP ID EP80811
- DOI -
- Views 184
- Downloads 0
Diabetic foot – the need for comprehensive multidisciplinary approach
Diabetes mellitus is considered to be civilization disease development of which is influenced by environmental changes. Diabetic foot (ulceration, infection, gangrene) is one of the most disabling complication of diabete...
Prevalence of hypertension in a sample of Polish population – baseline assessment from the prospective cohort ‘PONS’ study
Objective: The aim of this cohort study was to evaluate the prevalence of hypertension and cardiovascular risk factors in the studied population.Methods: Presented results are a part of the Polish-Norwegian Study (PONS)...
Therapeutic significance of curcumin and its role in cancer treatment
Curcumin has been used for thousands of years in traditional Indian medicine. Recent in vitro and in vivo animal studies have demonstrated its numerous properties such as: anti-inflammatory, antiviral, antibacterial, ant...
Expansion and aerobiology of Ambrosia artemisiifolia L. in Slovakia
[b]Introduction and objective.[/b] The invasive alien species [i]Ambrosia artemisiifolia[/i] cause environmental, agronomical and medical problems in many regions of the world, including Slovakia. The purpose of this stu...
Injuries caused by sharp instruments among healthcare workers – international and Polish perspectives
Health care workers (HCW) worldwide are especially exposed to injury by sharp instruments in the course of their duty. The most often executed procedures with injury risk are: intramuscular or subcutaneous injection (22%...