Characterisation of Yersinia Secretion Apparatus - Pathogenicity Island (Ysa-PI) of Yersinia enterocolitica 1B/O8 in Poland: an Idle Ysa Is a Specific Hallmark of the Epidemic Sensu Stricto Strain
Journal Title: Polish Journal of Microbiology - Year 2015, Vol 64, Issue 2
Abstract
[i][/i][i]Yersinia[/i] secretion apparatus (Ysa), the chromosomal type three secretion system (T3SS) is considered to contribute to virulence of high-pathogenicity[i] Yersina enterocolitica[/i] biovar 1B. DNA‑sequence of Ysa pathogenicity island was determined for clinical isolate DM0110 of [i]Y. enterocolitica [/i]1B/O8 with origin in Poland. We found a premature stop-codon in the regulatory gene [i]ysrR[/i] (mutation at position 269). Altered [i]ysrR[/i] was detected in all tested 78 isolates of [i]Y. enterocolitica [/i]1B/O8 collected from clinical samples in Poland from 2004 to 2013. Since aberrations in YsrR are considered to inactivate Ysa, our findings may suggest Ysa is not indispensable for [i]Y. enterocolitica[/i] 1B/O8 to infect humans.
Authors and Affiliations
Tomasz Wołkowicz, Katarzyna Zacharczuk, Natalia Rokosz-Chudziak, Waldemar Rastawicki, Rafał Gierczyński
Keywords
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