CHEMICAL PENETRATION ENHANCERS: FOR TRANSDERMAL DRUG DELIVERY SYSTEMS
Journal Title: Int J of Pharm Rev& Res - Year 2014, Vol 4, Issue 1
Abstract
The evolutionary development of the human skin as a protective potential barrier which keep noxious substances out of the body, also maintaining the body temperature and prevent excessive loss of water from the internal organs. Rather than its barrier properties, strategies have developed to deliver the drugs through the skin. One approach in improving transdermal drug delivery (across the skin) by reversibly decreasing the barrier resistance is the use of chemical penetration enhancers (CPEs). Numbers of compounds have been evaluated for penetration enhancing activity, including alcohols, azone, esters, glycols, fatty acids, pyrrolidones, sulphoxides, terpenes etc. The present review considers the various types of CPEs and their mechanisms of action. The emphasis is on in-vivo and in-vitro studies which focus on limitations associated with skin permeation collected data; penetration enhancers may disrupt the packing of intercellular lipid matrix, increasing drug partitioning into the tissue or intracellular keratin domains by acting as a solvent for the drug within the membrane. A further potential mechanism of action, for example as enhancers alters metabolic activity within the skin, or exerting an influence on the thermodynamic activity/solubility of the drug in its vehicle are also feasible, and also importance of penetration enhancers considered in this review
Authors and Affiliations
Saurabh Vinod Raut, , Lalita S. Nemade , Maya T. Desai , Shailejkumar D. Bonde , Shweta U. Dongare
Keywords
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