Chemokine Ligand-Receptor Axes for Therapeutic Targeting During Skin Regeneration
Journal Title: Journal of Dermatology Research - Year 2023, Vol 4, Issue 3
Abstract
Chemokines and their cognate receptor interactions regulate the balance between pro-inflammatory and anti-inflammatory signals to support the physiological functions of the skin. Chemokines also regulate the process of angiogenesis, epithelialization and collagen deposition. A severely dysregulated chemokine ligand-receptor network has been observed in chronic non-healing wounds and skin diseases. Evaluation of the chemokine signaling pathways in pathological skin conditions is essential for the development of targeted therapeutic interventions that can enhance skin regeneration. Although chemokines and their receptors serve as attractive targets for drug discovery, clinical trials to date have seen limited success, especially in skin regeneration. Repurposing of the already established drugs can overcome the limitations. Therefore, we identified a set of chemokines and chemokine receptors that are expressed during skin regeneration. Further, we provided a network of existing drugs targeting these chemokines and chemokine receptors that can be repurposed for enhancing skin regeneration in chronic wounds and skin diseases. This review underscores the pivotal role of chemokine ligand-receptors axes in complex wounds and skin diseases and highlights the preclinical and clinical breakthroughs targeting these networks for skin regeneration.
Authors and Affiliations
Subholakshmi Choudhury, Amitava Das
Keywords
Related Articles
- EP ID EP724143
- DOI https://doi.org/10.46889/JDR.2023.4308
- Views 65
- Downloads 0
Androgenetic Alopecia: A Study on The Efficacy of a Combined Protocol of Blue Light Photobiomodulation and Subcutaneous Infiltrations of Biomimetic Peptides
Androgenetic Alopecia (AGA) is a common condition affecting men and women, characterized by progressive hair follicle miniaturization and consequent hair loss. Blue light Photobiomodulation (PBM) by LED (Light emitting d...
Blood Group and Human Leucocyte Antigen Sub-Type as Determinants to Keloid Formation and Recurrence in Keloid Patients: A Prospective Longitudinal Cohort Study
The role of genetic factors in keloid formation is affirmed by the fact that keloids have been shown to occur among members of the same family. We undertook this study to determine whether there is any association betw...
Most Common Drug Eruptions by Pattern and Drug Class: A Review
Cutaneous drug reactions come in many different morphologies, distributions and severities ranging from pruritus and erythema to diffuse epidermal denudation requiring hospitalization. The wide variety of presentations a...
A New Dermatological Research Focus in the Era of COVID-19 Pandemic
In the era of COVID-19 pandemic, the significance of skin manifestations is more important than we think. Dermatologists have a unique opportunity to adequately describe skin manifestations of COVID-19, and make our co...
Improvements in Skin and Nail Psoriasis are Positively Correlated across Systemic Psoriasis Therapies
Objective: For clinical scenarios where patients have moderate to severe psoriasis and nail psoriasis, knowing whether skin response is correlated with nail response would provide insight into the relationship between ps...