Cholinesterase inhibitors in the “real world” setting: rivastigmine versus donepezil tolerability and effectiveness study
Journal Title: Archives of Medical Science - Year 2006, Vol 2, Issue 3
Abstract
Introduction: Comparative tolerability and effectiveness of donepezil and rivastigmine in clinical practice using a “real life” sample of patients diagnosed as having mild to moderate Alzheimer’s disease and treated in the memory clinic setting have not been properly studied to date. Material and methods: A retrospective, case records analysis of all patients (N=183) who had been prescribed either drug over the period of 3 years (1998-2000) and were seen for at least 6 months afterwards. Main outcome estimates were: for tolerability the likelihood to achieve recommended doses for both drugs and side effects profiles, for effectiveness clinical global impression of change (CGI) rating at 6 months after dose titration finished. Results: Numerically, more subjects on rivastigmine than on donepezil dropped out early due to side effects (14.6% vs 11.9%). A maximum approved dose (10 mg for donepezil and 12 mg for rivastigmine) has been achieved by significantly more patients on donepezil than on rivastigmine (p
Authors and Affiliations
Tomasz Sobow, Iwona Kloszewska
Keywords
Related Articles
- EP ID EP91184
- DOI -
- Views 202
- Downloads 0
The training needs of doctors working in England and in Poland with breastfeeding women
Introduction: The aim of this study was to compare the training needs of Polish and English medical practitioners in breastfeeding support skills. Self-assessed competence in 22 skill areas, perceived need for update of...
Depression in patients with oral or facial malignancy
A three-dimensional analysis of jejunal myenteric ganglia: a tool for interpretation of the optical recording
Introduction: Investigating functions of neurons in the enteric nervous system using imaging techniques (e.g. voltage sensitive dyes) requires precise data concerning the three-dimensional structure of enteric ganglia. R...
Preprocedural fibrinogen levels and MACE after percutaneous coronary intervention
Introduction: Fibrinogen is a risk factor for cardiovascular disease and is related to the severity of coronary atherosclerosis. According to many studies elevated fibrinogen levels in patients with coronary angioplast...
Verbal and non-verbal intelligence: dyslexic-dysgraphic students and normal students
Introduction: The present research aimed to compare the verbal and nonverbal intelligence of students with dyslexia-dysgraphia and normal students. Material and methods: Thirty students with dyslexia-dysgraphia and 30...