Chromophobe Renal Cell Carcinoma with Osteosarcomatous Differentiation: A Rare Case Report
Journal Title: Scholars Journal of Medical Case Reports - Year 2014, Vol 2, Issue 3
Abstract
Renal cell carcinoma sometimes exhibit sarcomatoid transformation. Sarcomatoid renal cell carcinoma (SRCC) is an uncommon but not rare neoplasm consisting of a typical renal cell carcinoma (RCC) associated intimately with a sarcomatoid component. It has been reported that sarcomatoid renal cell carcinomas constitute approximately 1.0% to 4.8% of the total number of renal parenchymal tumors. SRCC has an extremely poor prognosis Sarcomatoid transformation has been noted in virtually all types of RCC. However, chromophobe renal cell carcinoma (CRCC) is the most frequent renal cell carcinoma with a sarcomatoid component. Very few cases are reported in the literature, we report this additional with review of literature. A 50 year old woman referred a one month history of constant left flank pain. A left radical nepherectomy was performed. Gross pathological examination showed a tumor located in the upper part of the kidney with variegated appearance. Histologically, the tumor was composed of two intermixed distinct morphologic components; a chromophobe renal cell carcinoma and a high grade spindle cell sarcoma with osteosarcomatous areas. Our case represents sarcomatoid chromophobe renal cell carcinoma. This unusal variant has the potential to behave aggressively and to metastasize. Keywords: Chromophobecell, Histochemistry, Osteosarcomatous, Renal cell carcinoma, Sarcomatoid differentiation
Authors and Affiliations
Anunayi Jeshtadi, Neelaveni Neelala, Vijay Sreedhar Veldurthi, Nagendra Prasad, Santoshkiran G, Manimekhala. P
Keywords
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