CHRONIC EXPOSURE TO BISPHENOL A PRODUCES MORPHOLOGICAL DERANGEMENTS IN LIVER, KIDNEY AND HEART IN RATS
Journal Title: JOURNAL OF ANATOMICAL SCIENCES - Year 2018, Vol 26, Issue 1
Abstract
Introduction: Bisphenol A (BPA), an estrogenic compound is used in the manufacturing of plastics and also as coating for the inner linings of food packaging containers. It is reported to be an endocrine disruptor and produce toxicity in various organs. Since BPA exposure mainly occurs in the form of oral ingestion in humans, the present study was performed to examine the effects produced by the chronic exposure to BPA orally on kidney, liver and heart in rats. Material & Methods: Adult female rats of Charles Foster strain were used for the study. The rats were divided into two groups (n=6 in each group). In group 1, the rats were provided with food and water ad libitum whereas the rats of group 2 were fed with BPA containing pellets (2 µg/kg body weight/day) for 30 days. Thereafter the heart, kidneys and liver were excised and processed for histopathological study. Results: The histopathological examination of the organs in BPA fed rats showed major structural changes which manifested as loss of normal cytoarchitecture in all the three organs. Further there was significant reduction in the number of glomeruli in kidneys, degenerative changes in liver in the form of damage to portal triad and in heart the intercalated discs were damaged. Conclusion: Chronic exposure to BPA by oral route produces renal toxicity as loss of glomeruli; hepatotoxicity as cytoarchitecture loss and cardiotoxicity as damage of intercalated disc changes.
Authors and Affiliations
Mahendra Pant
Keywords
Related Articles
- EP ID EP544941
- DOI -
- Views 86
- Downloads 0
AN ESTIMATION OF CORRELATION BETWEEN MAXIMUM HEAD LENGTH AND THE STATURE OF HUMAN ADULTS OF NORTH INDIA
Introduction: The stature can be defined as the natural height of a person in erect position and is one of the criteria of personal identification. Stature has a definite and proportional biological relationship with eac...
MORPHOMETRIC STUDY OF THIRD VENTRICLE WIDTH IN NORTH INDIAN POPULATION: A CT STUDY
Introduction: Brain is one of the most complex and magnificent organs in the human body. Ventricular system of brain comprises of two lateral ventricles, third ventricle and a fourth ventricle. As brain ages, there is a...
AUTOSOMAL TRISOMY: A CYTOGENETIC STUDY IN LUCKNOW REGION
Introduction: Trisomy refers to chromosomal aneuploidy in which cells possess a karyotype that is not a multiple of the haploid complement. It is the most common numerical chromosomal abnormality. It usually occurs due t...
STUDY OF ANOGENITAL INDEX AND 2:4 DIGIT RATIO IN HUMAN FETUSES: AN ANTHROPOMETRIC STUDY FROM NORTHERN INDIA
Introduction: Anogenital index (AGI) and 2:4 digit ratio (2D:4D) are sexually dimorphic and found to be markers of androgen and androgen receptor (AR) status. Studies in adults and children have shown both AGI and 2D:4D...
SONOMAMMOGRAPHIC EVALUATION OF BREAST MASSES
Introduction: Sonomammography is an ideal, noninvasive, painless and accurate procedure used to detect and evaluate breast masses. In this study, detection evaluation and characterization of breast masses was done with u...