Chronic impairment of the vagus nerve function leads to inhibition of dopamine but not serotonin neurons in rat brain structures.

Journal Title: Pharmacological Reports - Year 2012, Vol 64, Issue 6

Abstract

BACKGROUNd: Recent clinical studies have shown that the dorsal motor nucleus of the vagus nerve is one of the brain areas that are the earliest affected by α-synuclein and Lewy body pathology in Parkinson's disease. This observation raises the question: how the vagus nerve dysfunction affects the dopamine system in the brain?

Authors and Affiliations

Agata Ziomber, Piotr Thor, Anna Krygowska-Wajs, Tomasz Załęcki, Marek Moskała, Irena Romańska, Jerzy Michaluk, Lucyna Antkiewicz-Michaluk

Keywords

Related Articles

Protective effects of betulin and betulinic acid against ethanol-induced cytotoxicity in HepG2 cells.

Plant triterpenes, such as oleanolic acid and betulin were described as hepatoprotectants active against cytotoxicity of acetaminophen or cadmium. The aim of this paper is to compare the cytoprotective activity of betuli...

Effect of luteinizing hormone-releasing hormone (LHRH) analogue treatment on a cytokine profile in prostate cancer patients.

The aim of the study was to test serum concentrations of the chosen cytokines in patients with prostate cancer (PCa) treated with an luteinizing hormone-releasing hormone (LHRH) analogue. We tested interleukin (IL)-2, IL...

Antihistaminic activity of carane derivatives in isolated guinea pig ileum.

Local anesthetics (LAs) inhibit membrane depolarization by reducing sodium and potassium conductance, and subsequent displacement of calcium ions from binding sites seems to occur. Histamine release appears to be a secre...

Effects of GABA(B) receptor ligands in rodent tests of anxiety-like behavior.

GABAergic hypothesis of anxiety was introduced many years ago, however, a limited number of supporting data were accumulated so far and the role of GABA(B) receptors in behavioral processes related to the anxiety disorde...

Exendin-4 reduces glycemia by increasing liver glucokinase activity: an insulin independent effect.

Exendin-4 is a stable peptide agonist of GLP-1 receptor that exhibits insulinotropic actions. Some in vivo studies indicated insulin-independent glucoregulatory actions of exendin-4. That finding prompted us to evaluate...

Download PDF file
  • EP ID EP103970
  • DOI -
  • Views 103
  • Downloads 0

How To Cite

Agata Ziomber, Piotr Thor, Anna Krygowska-Wajs, Tomasz Załęcki, Marek Moskała, Irena Romańska, Jerzy Michaluk, Lucyna Antkiewicz-Michaluk (2012). Chronic impairment of the vagus nerve function leads to inhibition of dopamine but not serotonin neurons in rat brain structures.. Pharmacological Reports, 64(6), 1359-1367. https://www.europub.co.uk/articles/-A-103970