Circumsporozoite protein (CSP) genetic diversity in Indian Plasmodium vivax.
Journal Title: International Journal of Biological Innovations - Year 2022, Vol 4, Issue 2
Abstract
India is one of the Plasmodium vivax endemic countries and contributes the highest number of malaria cases worldwide. P. vivax CSP (PvCSP) is one of the most extensively studied antigen and is considered to be a leading malaria vaccine candidate gene. VK210 and VK247 are the two variants described in the central repeat region of P. vivax CSP gene. VK210 (98%) is found to be more prevalent as compared to VK247 (2%) in Indian context. It was noticed that different geographical regions show diversity in nucleotides as well as in haplotype with respect to PvCSP gene of Indian isolates. As natural selection always plays an important role in shaping genomic diversity in Indian P. vivax, the central repeat region of PvCSP gene of all the five-populations found to be under strong purifying selection. In this region, a number of synonymous mutations were found to be higher in number as compared to non-synonymous mutation, which clearly indicated that PvCSP gene is involved in invasion of hepatocytes in the host body and the parasite can’t afford non-synonymous changes in this region. The present study helps us to understand the nature of P. vivax population in India, and also that might be helpful in planning the development of PvCSP-based vaccine in India.
Authors and Affiliations
Nisha Siwal
Keywords
Related Articles
- EP ID EP709937
- DOI https://doi.org/10.46505/IJBI.2022.4204
- Views 83
- Downloads 0
SEASONAL VARIATION IN PRIMARY PRODUCTIVITY AND MACROPHYTES OF GUTHIA TAAL, BAHRAICH (U.P.)
Seasonal variations in primary productivity, respiration rate, chlorophyll content and macrophytes biomass were carried out during July, 2019 to June, 2020. Grass primary productivity 3 (GPP) and net primary productivi...
Polymorphism among different families of Dipteran order: Comparison of RAPD data.
Random amplified polymorphic DNA-Polymerase Chain Reaction (RAPD-PCR) data was compared to assess heterozygosity and genetic variability among different members belonging to family Muscidae, Sarcophagidae and Tephritid...
Recycling of sewage in Aquaculture: An overview.
Sewage contains huge quantities of different types of nutrients which are utilized in fish culture; hence recycling of this wastewater in a productive way is the acute demand of the future of aquaculture. Raw sewage ca...
Comparative morphometric, meristic and osteological studies on adult and young hilsa (Tenualosa ilisha).
Tenualosa ilisha (matured/adult) and jatka (immature/young), locally known as Ilish, is designated as the national fish of Bangladesh. Both the stages were collected from different fish markets from Savar, Bangladesh dur...
Leaf dust accumulation and its impact on Chlorophyll content of Azadirachta indica and Bauhinia variegata developing in the proximity of Jaypee Cement Plant, Rewa (M.P.), India.
Foliar surface of plant is continuously exposed to the surrounding atmosphere and is the main receptor of dust. Dust affects the photosynthesis, respiration, transpiration and allows the penetration of phytotoxic gaseo...